The clinical and instrumental evaluation of the efficacy of enalapril and telmisartan in the correction of cardiac structural and functional changes in essential hypertension

The effects of enalapril and telmisartan on hemodynamic parameters, left ventricular structural and functional parameters, and artery endothelial vasomotor function were studied in patients with grades I and II essential hypertension (EH) and left ventricular diastolic dysfunction by the abnormal relaxation type. The study enrolled 49 patients (mean age 48.3±3.2 years). Group 1 (n = 24) was treated with enalapril (enap); Group 2 (n = 25) received telmisartan (micardis). The examination encompasses 24-hour blood pressure (BP) monitoring, echocardiography, and duplex scanning of the brachial artery. During enalapril therapy, the systolic and diastolic BP goals were achieved in 79.2 and 70.8% of the patients, respectively, which was attended by a reduction in the number of non-dippers and night-pickers in 54.2% of cases. In addition to effective control of systolic (92%) and diastolic (96%) BP, 30-week telmisartan therapy ensured daily profile normalization in 90% (of the patients with abnormal circadian rhythm) with improved artery endothelial vasomotor function, positive structural and geometric changes in the left cardiac portions, and better left ventricular diastolic function, without suppressing myocardial contractility.

essential hypertension, cardiac and vascular remodeling, left ventricular diastolic dysfunction, angiotensin II receptor antagonists