Email this article Laboratory markers of toxoplasmosis in heart recipients
- Authors: Abbazova E.V.1, Goncharov D.B.1, Domonova E.A.2, Silveystrova O.Y.2, Kovaleva V.A.1, Titova I.V.1, Zakharevich V.M.3, Kormilitsyna V.G.3, Muminov I.I.3, Koloskova N.N.3, Khalilulin T.A.3, Gabrielyan N.I.3
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Affiliations:
- N.F. Gamaleya Federal Research Center of Epidemiology and Microbiology
- Central Research Institute of Epidemiology
- V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
- Issue: Vol 27, No 3 (2021)
- Pages: 237-245
- Section: Clinical medicine
- URL: https://journals.rcsi.science/0869-2106/article/view/101032
- DOI: https://doi.org/10.17816/0869-2106-2021-27-3-237-245
- ID: 101032
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Abstract
BACKGROUND. The number of organ transplantation surgeries is growing every year, including heart transplantion. The full spectrum of infections in heart transplant recipients is not well understood. One of the infectious agents that is particularly difficult to recognize is Toxoplasma gondii (T. gondii).
AIM: This work determines the informative value of detecting laboratory markers of toxoplasmosis in patients after heart transplantation to identify active forms of invasion.
MATERIALS AND METHODS: This investigation studied 121 heart recipients (95 men and 26 women) at different times after transplantation (several days to 12 years). Markers of Toxoplasma invasion were determined in blood sera, namely antibodies of the IgG, IgM, and IgA classes to T. gondii, avidity index of IgG antibodies to T. gondii, and DNA of the pathogen.
RESULTS: In 60 patients (49.6±4.5%) after heart transplantation, markers of Toxoplasma invasion were identified. In 20 (16.5±3.6%) cases, markers of active invasion were revealed, namely IgM and IgA antibodies to T. gondii in six and 11 patients, respectively, low-grade IgG antibodies to T. gondii in three patients, and DNA of the pathogen in two cases. Based on the totality of studies, it was determined that the disease activity in 75% of cases was due to its reactivation, whereas in the other cases, it was a recent infection. Laboratory signs of toxoplasmosis reactivation occurred mainly during the first year after transplantation, which was probably associated with the intensity of immunosuppressive therapy.
CONCLUSIONS: It was revealed that the most compelling studies indicating early signs of toxoplasmosis reactivation include detection of IgA antibodies to T. gondii and DNA of the pathogen. Further joint research is required by clinicians, epidemiologists, and laboratory diagnostics specialists to study the aspects of toxoplasmosis and disease diagnostics and preventionin patients after heart transplantation.
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##article.viewOnOriginalSite##About the authors
Evgeniya V. Abbazova
N.F. Gamaleya Federal Research Center of Epidemiology and Microbiology
Author for correspondence.
Email: janifer@inbox.ru
ORCID iD: 0000-0001-6328-8142
MD, Cand. Sci. (Med.)
Russian Federation, MoscowDmitriy B. Goncharov
N.F. Gamaleya Federal Research Center of Epidemiology and Microbiology
Email: goncharov_toxo@mail.ru
ORCID iD: 0000-0002-0250-4902
MD, Cand. Sci. (Biol.)
Russian Federation, MoscowElvira A. Domonova
Central Research Institute of Epidemiology
Email: elvira.domonova@pcr.ms
ORCID iD: 0000-0001-8262-3938
MD, Cand. Sci. (Biol.)
Russian Federation, MoscowOlga Yu. Silveystrova
Central Research Institute of Epidemiology
Email: olga.silveystrova@pcr.ms
ORCID iD: 0000-0001-8412-9765
Russian Federation, Moscow
Vasilisa A. Kovaleva
N.F. Gamaleya Federal Research Center of Epidemiology and Microbiology
Email: vasilisa.Kovaliova@gmail.com
ORCID iD: 0000-0003-0215-4938
Russian Federation, Moscow
Irina V. Titova
N.F. Gamaleya Federal Research Center of Epidemiology and Microbiology
Email: i-titova-54@yandex.ru
MD, Cand. Sci. (Med.)
Russian Federation, MoscowVyacheslav M. Zakharevich
V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Email: zaharslava@yandex.ru
ORCID iD: 0000-0002-1090-6901
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowViktoriya G. Kormilitsyna
V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Email: v16k@rambler.ru
ORCID iD: 0000-0002-6475-3904
Russian Federation, Moscow
Ilhomhodzha I. Muminov
V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Email: scorpion_if@mail.ru
ORCID iD: 0000-0002-7509-1440
MD, Cand. Sci. (Med.)
Russian Federation, MoscowNadezhda N. Koloskova
V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Email: nkrasotka@mail.ru
ORCID iD: 0000-0002-5819-9046
MD, Dr. Sci. (Med.)
Russian Federation, MoscowTimur A. Khalilulin
V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Email: timur-medicina@list.ru
ORCID iD: 0000-0002-6068-4462
MD, Cand. Sci. (Med.)
Russian Federation, MoscowNina I. Gabrielyan
V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs
Email: labgso@mail.ru
ORCID iD: 0000-0003-1941-8311
MD, Dr. Sci. (Med.)
Russian Federation, MoscowReferences
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