Synthesis and discovery of a water-soluble ureid of galodif with succinic acid
- 作者: Kuksenok V.1, Cui Y.1, Shtrykova V.1, Filimonov V.1, Shushpanova T.2
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隶属关系:
- Kizhner Research Center, National Research Tomsk Polytechnic University
- Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
- 期: 卷 59, 编号 9 (2023)
- 页面: 1228-1232
- 栏目: Articles
- URL: https://journals.rcsi.science/0514-7492/article/view/141691
- DOI: https://doi.org/10.31857/S0514749223090136
- EDN: https://elibrary.ru/XUTHHQ
- ID: 141691
如何引用文章
详细
For the first time, a new acyl ureide of the anticonvulsant and anti-alcohol drug galodif (3-chlorobenzhydryl urea) with succinic acid was obtained and studied. The synthesis was carried out by the acylation of galodif with succinic anhydride in presence of certain acids. Unlike galodif, which is practically insoluble in water, the resulting benzhydryl ureide is soluble in aqueous media and can potentially exhibit greater bioavailability and can be used as a liquid dosage form and prodrug with prolonged action.
作者简介
V. Kuksenok
Kizhner Research Center, National Research Tomsk Polytechnic University
Email: kukver89@tpu.ru
Y. Cui
Kizhner Research Center, National Research Tomsk Polytechnic University
V. Shtrykova
Kizhner Research Center, National Research Tomsk Polytechnic University
V. Filimonov
Kizhner Research Center, National Research Tomsk Polytechnic University
T. Shushpanova
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
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