Synthesis of (3 S ,4 S )-4-Acetyl-3-(1 R )-1-hydroxyethyl1-(4-methoxyphenyl)azetidin-2-one

Synthesis of (3S,4S)-4-Acetyl-3-(1R)-1-hydroxyethyl1-(4-methoxyphenyl)azetidin-2-one

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The synthesis of the title compound from l-threonine with the participation of β-metallyl chloride amide in the N -alkylation step is described.

2-bromo-3-hydroxybutanamides, β-metallyl chloride, N-alkylation, ozonolysis, intramolecular "epoxide-enolate" cyclization, azetidin-2-ones

Ufa Institute of Chemistry UFRC RAS

Ufa Institute of Chemistry UFRC RAS

Ufa Institute of Chemistry UFRC RAS

Ufa Institute of Chemistry UFRC RAS

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