A New Method for Constructing Aryl-Substituted 3,3,4-Trihydroxy-2,3,4-Tetrahydrobenzimidazo[2,1-b][1,3]Thiazin-5-ium Salts

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Abstract

By the reaction of acetal- containing chloroxyranes and - chloroketones with N-ethyl-2-mercaptobenzimidazole in a 95% ethanol solution using microwave irradiation, a new preparative method for the synthesis of previously undescribed 3,3,4-trihydroxybenzimidazo[2,1-b][1,3]thiazinium salts with high yields up to 93%, of interest to medicinal chemistry, has been developed.

About the authors

F. I. Guseinov

Kosygin State University of Russia; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: guseinoveltos@mail.ru
ORCID iD: 0000-0002-6769-0232
Moscow, Russia

L. M. Kustov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

ORCID iD: 0000-0003-2312-3583
Moscow, Russia

K. A. Afanasyeva

Kosygin State University of Russia; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

ORCID iD: 0009-0007-3729-921X
Moscow, Russia

E. V. Shuvalova

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

ORCID iD: 0000-0002-2657-7735
Moscow, Russia

K. I. Kobrakov

Kosygin State University of Russia; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

ORCID iD: 0000-0001-8940-0112
Moscow, Russia

Yu. L. Selyakin

MIREA-Russian Technology University (Lomonosov Institute of Fine Chemical Technology)

ORCID iD: 0000-0002-7027-378X
Moscow, Russia

A. V. Stepanov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

ORCID iD: 0009-0007-1797-2833
Moscow, Russia

A. I. Samigullina

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

ORCID iD: 0000-0002-6791-9973
Moscow, Russia

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