Features of Synthesis of 5(3)-Polyfluoromethylpyrazole-3(5)-Carbaldehyde and Their Dimethyl Acetals

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Abstract

Reactions of difluoroacetyl- and trifluoroacetylpyruvaldehyde dimethyl acetals with methyl and phenylhydrazine in methanol occur regioselectively and make it possible to obtain N-methyl- and N-phenyl-substituted 5-polyfluoromethylpyrazole-3-carbaldehyde and their dimethyl acetals in good yields. Regioisomeric N- methyl- and N-phenyl-substituted 3-polyfluoromethylpyrazole-5-carbaldehyde and their dimethyl acetals were synthesized in moderate yields by reacting the same reagents in trifluoroethanol or acetic acid.

About the authors

D. V. Belyaev

I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B.N. Yeltsin

Email: D734698@yandex.ru
Yekaterinburg, Russia; Yekaterinburg, Russia

D. L. Chizhov

I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Yekaterinburg, Russia

G. L. Rusinov

I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Yekaterinburg, Russia

V. N. Charushin

I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Yekaterinburg, Russia

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