Photocatalytic Fluoroalkylation of Derivatives of 3-Aminopyrazole

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Abstract

The reaction of 3-aminopyrazole derivatives with pentafluoroethyl iodide in the presence of a ruthenium photocatalyst under irradiation with blue light is described. 3-Aminopyrazoles containing a substituent at positions 4 or 5 gave the corresponding fluoroalkylation products. In the case of N-Boc derivatives of 3-aminopyrazole, the selectivity of radical fluoroalkylation depends on the nature of the structure of the N-Boc pyrazole.

About the authors

D. S. Koltun

N.D. Zelinsky Institute of Organic Chemistry

Moscow, Russia

V. V. Levin

N.D. Zelinsky Institute of Organic Chemistry

Moscow, Russia

A. D. Dilman

N.D. Zelinsky Institute of Organic Chemistry

Email: dilman@ioc.ac.ru
Moscow, Russia

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