Email this article Synthesis and properties for enaminoketoamides of 2,2-dimethyl-2,3-dihydrobenzo[f]isoquinoline series
- Authors: Mikhailovskii A.G1, Peretyagin D.A1
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Affiliations:
- Perm State Pharmaceutical Academy
- Issue: Vol 59, No 7 (2023)
- Pages: 946-951
- Section: Articles
- URL: https://journals.rcsi.science/0514-7492/article/view/141662
- DOI: https://doi.org/10.31857/S051474922307008X
- EDN: https://elibrary.ru/HTLEUB
- ID: 141662
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Abstract
The reaction of 1-R-6,6-dimethyl-5,6-dihydrobenzo[ f ]pyrrolo[2,1- a ]isoquinoline-8,9-diones (R = H, morpholinocarbonyl) with ammonia, morpholine, aniline and 1-naphtylamine proceeds with opening of dioxopyrroline cycle and forming enaminoketoamides. The conditions of reaction depends on the nature of nucleophile: ammonia and morpholine readily react at 20°C, the reaction with aromatic amines requires reflux in glacial acetic acid.
About the authors
A. G Mikhailovskii
Perm State Pharmaceutical Academy
Email: neorghim@pfa.ru
D. A Peretyagin
Perm State Pharmaceutical Academy
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