Properties of influenza viruses that caused epidemic increases in morbidity in Russia and countries of the world during 2022–2023. The effectiveness of vaccine prophylaxis

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Abstract

The purpose of this work was to determine the characteristics of the circulation of various viral respiratory pathogens during the epidemic season 2022–2023 against the background of the ongoing evolutionary variability of SARS-CoV-2.

Materials and methods. The article uses methods used in «traditional» and «hospital» epidemiological surveillance of acute respiratory viral infections.

Results and discussion. The period from October 2022 to September 2023 was characterized by early and high activity of influenza A(H1N1)pdm09 virus, which was replaced by influenza B virus. The antigenic and genetic properties of strains were closely related to influenza vaccines viruses recommended by WHO experts for the current season. The effectiveness of influenza vaccines was confirmed (75.0%). All of the studied influenza A(H1N1)pdm09, A(H3N2) and B epidemic strais retained sensitivity to drugs with antineuraminidase activity. The structure and share of other ARVI pathogens have changed somewhat compared to the previous season: There was a tendency to increase the activity of HAdV and HMPV; almost equivalent activity of HRsV, HRV, HCoV and HBoV; and a decrease in HPIV activity. At the same time, the frequency of other ARVI pathogens did not reach the indicators of the pre-pandemic COVID-19 period. The rationale for updating the composition of influenza vaccines for the countries of the Northern Hemisphere in the 2023–2024 season is given.

About the authors

Elena I. Burtseva

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Author for correspondence.
Email: elena-burtseva@yandex.ru
ORCID iD: 0000-0003-2518-6801

Dr. Sci. (Medicine), Head of influenza etiology and epidemiology laboratory National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Ludmila V. Kolobukhina

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: lkolobuchina@yandex.ru
ORCID iD: 0000-0001-5775-3343

Dr. Sci. (Medicine), prof., Head of Department, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Anna D. Panova

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: ainushgnomello@gmail.com
ORCID iD: 0000-0002-9322-6273

junior researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Evgeniya A. Mukasheva

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: mukasheva_evgeniya@mail.ru
ORCID iD: 0000-0002-5688-5309

researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Kirill G. Krasnoslobodtsev

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: kkg_87@mail.ru
ORCID iD: 0000-0003-1745-9128

researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Elena S. Kirillova

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: esshevchenko@yandex.ru
ORCID iD: 0000-0001-7977-7530

PhD (Medicine), leading researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Natalia V. Breslav

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: n.belyakova1983@gmail.com
ORCID iD: 0000-0002-6946-5119

PhD (Biology), senior researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Svetlana V. Trushakova

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: s.trushakova@gmail.com
ORCID iD: 0000-0002-9610-3041

PhD (Biology), senior researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Irina A. Komarova

Pacific State Medical University of the Ministry of Health of the Russian Federation

Email: mikhaira@yandex.ru
ORCID iD: 0000-0003-0483-7433

assistent, Department of Infectious Diseases, Pacific State Medical University of the Ministry of Health of the Russian Federation

Russian Federation, 690002, Primorsky Krai, Vladivostok

Elena L. Feodoritova

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: flulab@mail.ru
ORCID iD: 0000-0002-1472-1357

researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Liliya N. Merkulova

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: merkulova0320@yandex.ru
ORCID iD: 0000-0002-7260-0879

PhD (Medicine), leading researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Irina N. Khlopova

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: khlopova.ira@yandex.ru
ORCID iD: 0000-0002-7419-590X

PhD (Medicine), leading researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Irina S. Kruzhkova

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: irina-kru@yandex.ru
ORCID iD: 0000-0002-1983-481X

junior researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Anna V. Ignatieva

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: valgella@yandex.ru
ORCID iD: 0000-0001-6206-2299

PhD (Biology), senior researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Anastasia S. Krepkaia

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: nastya18-96@mail.ru
ORCID iD: 0000-0002-7272-4011

junior researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Andrey B. Komissarov

Research institute of influenza named after A.A. Smorodintsev of Ministry of Health

Email: andrey.komissarov@influenza.spb.ru
ORCID iD: 0000-0003-1733-1255

Head of molecular virology laboratory, Research institute of influenza named after A.A. Smorodintsev of Ministry of Health

Russian Federation, 197022, St. Petersburg

Andrei A. Pochtovyi

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: a.pochtovyy@gamaleya.org
ORCID iD: 0000-0003-1107-9351

PhD (Biology), senior researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Daria D. Kustova

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: kustovad70@gmail.com
ORCID iD: 0000-0002-8382-275X

junior researcher, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Vladimir A. Gushchin

National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Email: wowaniada@yandex.ru
ORCID iD: 0000-0002-9397-3762

Dr. Sci. (Biology), Head of laboratory, National Research Centre of Epidemiology and Microbiology named after honorary academician N.F. Gamaleya of Ministry of Health

Russian Federation, 123098, Moscow

Igor N. Tyurin

Clinical Hospital for Infectious Diseases No. 1, Department of Health of Moscow

Email: tyurin.dti@yandex.ru
ORCID iD: 0000-0002-5696-1586

PhD (Medicine), chief physician, Clinical Hospital for Infectious Diseases No. 1, Department of Health of Moscow

Russian Federation, 125367, Moscow

Alexey A. Samkov

Clinical Hospital for Infectious Diseases No. 1, Department of Health of Moscow

Email: a.a.samkov@yandex.ru
ORCID iD: 0000-0002-0365-3096

deputy chief physician, Clinical Hospital for Infectious Diseases No. 1, Department of Health of Moscow

Russian Federation, 125367, Moscow

Natalya А. Antipyat

Clinical Hospital for Infectious Diseases No. 1, Department of Health of Moscow

Email: natadoc70@bk.ru
ORCID iD: 0000-0001-8578-2838

deputy chief physician, Clinical Hospital for Infectious Diseases No. 1, Department of Health of Moscow

Russian Federation, 125367, Moscow

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Supplementary files

Supplementary Files
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1. JATS XML
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2. Fig. 1. The frequency of positive samples for influenza, SARS-CoV-2 and ARVI during the epidemic season 2022–2023 in certain territories of the Russian Federation

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3. Fig. 2. The share of influenza viruses during the epidemic season 2022–2023 in different regions of the Russian Federation (according to the Centers of Hygiene and Epidemiology of cities, regions, republics).

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Copyright (c) 2024 Burtseva E.I., Kolobukhina L.V., Panova A.D., Mukasheva E.A., Krasnoslobodtsev K.G., Kirillova E.S., Breslav N.V., Trushakova S.V., Komarova I.A., Feodoritova E.L., Merkulova L.N., Khlopova I.N., Kruzhkova I.S., Ignatieva A.V., Krepkaia A.S., Komissarov A.B., Pochtovyi A.A., Kustova D.D., Gushchin V.A., Tyurin I.N., Samkov A.A., Antipyat N.А.

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