To the 55th аnniversary of the Department of Virus Ecology with the Scientific and Practical Center for the Ecology and Epidemiology of Influenza (D.I. Ivanovsky Institute of Virology of the N.F. Gamaleya National Research Center for Epidemiology and Microbiology of the Ministry of Health of Russian Federation)

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The article presents historical aspects and key achievements of the Department of Virus Ecology (DVE) with the Scientific and Practical Center for Influenza Ecology and Epidemiology, which was established in 1969 at the D.I. Ivanovsky Institute of Virology of Academy of Medical Sciences of the USSR. For over 50 years, the DVE has been devoted to addressing fundamental issues in virus ecology, including the formation of viral populations in nature, and conducting comprehensive large-scale studies in the interest of the state’s biosecurity. The department’s primary focus is on particularly dangerous (arboviral) and socially significant (influenza and other acute respiratory viral infections, parenteral hepatitis) viral infections. As a result of this extensive work in the Northern Eurasia region, over 2,000 strains of zoonotic viruses (17 genera, 8 families), ecologically linked to various arthropod vectors and vertebrate hosts, have been isolated. Many of them have been registered in international catalogs as new species. The role of these isolated viruses in human pathology has been studied, new viral infections have been described, and diagnostic preparations have been developed. The scientific results obtained by the department are of high priority and internationally recognized.

作者简介

Dmitry Lvov

D.I. Ivanovsky Institute of Virology of N.F Gamaleya National Research Center of Epidemiology and Microbiology of Ministry of Health of Russian Federation

编辑信件的主要联系方式.
Email: dk_lvov@mail.ru
ORCID iD: 0000-0001-8176-6582

Academician of the Russian Academy of Sciences, Professor, Doctor of Medical Sciences, Head of the Department of Virus Ecology with the Scientific and Practical Center for Ecology and Epidemiology of Influenza D.I. Ivanovsky Institute of Virology of N.F Gamaleya National Research Center of Epidemiology and Microbiology of Ministry of Health of the Russian Federation

俄罗斯联邦, 123098, Moscow

Sergey Alkhovsky

D.I. Ivanovsky Institute of Virology of N.F Gamaleya National Research Center of Epidemiology and Microbiology of Ministry of Health of Russian Federation

Email: anyuta6549@yandex.ru
ORCID iD: 0000-0001-6913-5841

Corresponding Member of the Russian Academy of Sciences, Doctor of Biological Sciences, Head of the Laboratory of Biotechnology D.I. Ivanovsky Institute of Virology of N.F Gamaleya National Research Center of Epidemiology and Microbiology of Ministry of Health of the Russian Federation

俄罗斯联邦, 123098, Moscow

参考

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2. Fig. 1. E.N. Pavlovsky in the circle of teachers and students of the VI course of the General Biology and Parasitology Department of the S.M. Kirov Military Medical Academy, 1955. Top row: Yu.V. Chicherin, A.A. Gorovenko, D.K. Lvov, K.F. Dobrovolsky, A.A. Karyakin; middle row: B.N. Nikolaev, G.G. Smirnov, E.N. Pavlovsky, A.V. Gutsevich; bottom row: V.N. Motorin, V.S. Nedelko, N.M. Ushakov, V.I. Shut.

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3. Fig. 2. Founder and Head of the Virus Ecology Department (1969–2023), Dr. Dmitry Konstantinovich Lvov, Professor, Academician of the Russian Academy of Sciences. Director of the D.I. Ivanovsky Research Institute of Virology (1987–2014). Honorary Doctor of the Military Medical Academy of the Order of Lenin named after S.M. Kirov (2004).

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4. Fig. 3. E.I. Burtseva, Dr. Sc. (Med.), Head of the Virus Ecology Department since 2023, Head of the Influenza Etiology and Epidemiology Laboratory.

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5. Fig. 4. S.V. Alkhovsky, Dr. Sc. (Biol.), corresponding member of the Russian Academy of Sciences, head of the Biotechnology Laboratory of the Virus Ecology Department.

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6. Fig. 5. I.T. Fedyakina, Ph.D., Head of the Virus Ecology Laboratory of the Virus Ecology Department.

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7. Fig. 6. Meridional sounding of the USSR territory – studies on identification of biological viral background similar to radiation and landscape-climatic zoning.

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8. Fig. 7. Mosquito infestation and immunity in the population to California encephalitis serogroup viruses.

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9. Fig. 8. Distribution of Sindbis virus, the Karelian fever pathogen (Okelbo fever, Pogost’s disease) (Togaviridae: Alphavirus) in Fenoscandia.

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10. Fig. 9. Locations of Getah virus (Togaviridae: Alphavirus) isolation in Eastern Siberia, the Far East, and Mongolia.

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11. Fig. 10. New Nairoviruses (Nairovirus) associated with bats Issyk-Kul (ISKV) and Uzun-Agach (UZAV) viruses.

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12. Fig. 11. Ixodes uriae ticks (Tyulenii Island in the Sea of Okhotsk).

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13. Fig. 12. Nesting colonies of Thin-billed Buzzards (Uria aalge) on the Commander Islands.

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14. Fig. 13. Population interactions of WNF virus with arthropod vectors and vertebrate hosts.

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15. Fig. 14. Winners of the State Prize for Science and Technology (1999).

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16. Fig. 15. Founders of the concept of natural foci of influenza A virus (Orthomyxoviridae, Influenza A virus). From left to right Graham Laver (Australia), Dmitry Lvov (USSR), Robert Webster (USA).

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17. Fig. 16. Influenza A viruses in the biosphere.

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18. Fig. 17. Isolation of influenza A virus strains in natural foci of Northern Eurasia (1962–2011).

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19. Fig. 18. Causes and consequences of HPAI / H5N1 spread into Northern Eurasia (fall 2005).

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20. Fig. 19. Characterization of seasonal acute respiratory viral infection (ARVI) pathogens.

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21. Fig. 20. Detection of circulating bat coronaviruses (Hosta-1 and Hosta-2) related to SARS-CoV-2 in southern Russia (northern coast of the Black Sea) in 2020. The identified viruses are able to bind the ACE2 receptor of bats, Hosta-2 virus also effectively binds to the human ACE2 receptor and is capable of using it to infect the cell.

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