The prevalence of IGM antibodies to Zika virus in pregnant women in Northern Nigeria

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Abstract

Introduction. Zika virus (ZIKV) infection during pregnancy can result in severe outcomes for both the pregnant woman and the developing fetus.

The objective of this study was to investigate the prevalence of Zika virus infection among pregnant women who sought healthcare services at Ahmadu Bello University Teaching Hospital.

Materials and methods. Serum samples were collected and analyzed using Enzyme Linked Immunoassay and RT-qPCR methods, while a structured questionnaire was used to gather relevant information about the participants.

Results. The results showed that 53 out of the 180 pregnant women tested positive for Anti-Zika IgM antibodies, which represents a 29.4% prevalence rate. Subsequent RT-qPCR analysis found that only 6 out of the 53 positive samples contained Zika virus RNA. Fever and headache were the most commonly reported symptoms related to the infection.

Conclusion. These findings indicate a potential outbreak of Zika fever in Northern Nigeria emphasizing the importance for pregnant women to take precautions to avoid getting infected.

About the authors

Hafeez Aderinsayo Adekola

Olabisi Onabanjo University

Author for correspondence.
Email: hadeinsayor@gmail.com
ORCID iD: 0000-0003-3132-3315

PhD, University Lecturer, Lecturer II of Department of Microbiology

Nigeria, Ago Iwoye, Ogun State

David Ajiboye Ojo

Federal University of Agriculture

Email: daojo3@yahoo.com
ORCID iD: 0000-0001-5762-7689

PhD, University Lecturer, Professor of Department of Microbiology

Nigeria, Abeokuta, Ogun State

Saka Adebayo Balogun

Federal University of Agriculture

Email: balogunsa@hotmail.com
ORCID iD: 0000-0002-0045-602X

PhD, University Lecturer, Professor of Department of Microbiology

Nigeria, Abeokuta, Ogun State

Morenike Aderonke Dipeolu

Federal University of Agriculture

Email: dmorenike@gmail.com
ORCID iD: 0000-0002-8479-6135

PhD, University Lecturer, Professor of Department of Microbiology

Russian Federation, Abeokuta, Ogun State

Musa Mohammed

Ahmadu Bello University

Email: bokanee78@gmail.com
ORCID iD: 0000-0001-5240-2130

MSc, Medical Laboratory Scientist, Immunologist of Department of Medicine

Nigeria, Zaria, Kaduna State

Daniel Stephen Adejo

Ahmadu Bello University

Email: adedansteve@gmail.com
ORCID iD: 0000-0003-0246-0767

MSc, Medical Laboratory Scientist, Pathologist of Department of Obstetrics and Gynaecology

Nigeria, Zaria, Kaduna State

Rabi'at Muhammad Aliyu

Ahmadu Bello University Teaching Hospital

Email: rabaahmb@ymail.com
ORCID iD: 0000-0001-5735-9709

MSc, Medical Laboratory Scientist, Pathologist of Department of Obstetrics and Gynaecology

Nigeria, Zaria, Kaduna State

Mohammed Asara Abdullahi

Ahmadu Bello University Teaching Hospital

Email: asara1744@gmail.com
ORCID iD: 0000-0003-3820-8264

MSc, Medical Laboratory Scientist, Pathologist of Department of Internal Medicine

Nigeria, Zaria, Kaduna State

Nana Hawwa Madugu

Ahmadu Bello University Teaching Hospital

Email: madugu20007@yahoo.com
ORCID iD: 0000-0002-8832-4215

PhD, University Lecturer, Professo of Department of Obstetrics and Gynaecology

Nigeria, Zaria, Kaduna State

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Copyright (c) 2023 Adekola H.A., Ojo D.A., Balogun S.A., Dipeolu M.A., Mohammed M., Adejo D.S., Aliyu R.M., Abdullahi M.A., Madugu N.H.

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