In situ gels as a modern method of intranasal vaccine delivery

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Abstract

The continuous emergence of new pathogens and the evolution of microbial drug resistance make it absolutely necessary to develop innovative, effective vaccination strategies. Use of nasal vaccination can increase convenience, safety, cause both local and systemic immune reactions. Intranasal administration nevertheless has a number of shortcomings that can be overcome by using the latest achievements of pharmaceutical science. One of the aspects of such solution may be the use of systems for the production of intranasal vaccines in situ – polymer compositions that provide a directed sol-gel transition controlled by the physiological conditions of the nasal cavity. At the same time, the gelation of the administered dose in contact with the nasal mucosa involves prolonged exposure of the drug at the injection site, greater mucoadhesion, counteraction to mucociliary clearance, modified and more complete release. A number of both foreign and domestic manufacturers produces polymers such as chitosan, gums, polyoxyethylene and polyoxypropylene block copolymers (poloxamers, proxanols), carbomers. For effective pharmaceutical development of new intranasal IBD delivery systems corresponding to the QbD concept, not only the knowledge of the range of excipients is necessary, but also simple, accessible, and reproducible methods for determining indicators that define the critical parameters of such delivery systems. In accordance with the conducted scientific search, the main indicators of standardization of in situ intranasal systems were identified: temperature and time of gel formation, gel strength, rheological characteristics, mucoadhesion, release, nasal mucociliary clearance time.

About the authors

Elena O. Bakhrushina

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Author for correspondence.
Email: bakhrushina_e_o@staff.sechenov.ru
ORCID iD: 0000-0001-8695-0346

PhD, Associate Professor, Associate Professor of the department of Pharmaceutical Technologies

Russian Federation, 119048, Moscow

Joseph B. Mikhel

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Email: mikheliosif@gmail.com
ORCID iD: 0000-0002-2866-0049

Student of the 5th year of the OD of the Institute of Pharmacy. A.P. Nelyubina

Russian Federation, 119048, Moscow

Valeria M. Kondratieva

National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of Russia

Email: 1999valeriak@mail.ru
ORCID iD: 0000-0001-9163-4516

Graduate student

Russian Federation, 123098, Moscow

Natalia B. Demina

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Email: demina_n_b@staff.sechenov.ru
ORCID iD: 0000-0003-4307-8791

Doctor of Pharmaceutical Sciences, Professor, Professor at the department of Pharmaceutical and Biomedical Technology

Russian Federation, 119048, Moscow

Tatyana V. Grebennikova

National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of Russia

Email: t_grebennikova@mail.ru
ORCID iD: 0000-0002-6141-9361

Doctor of Biological Sciences, Professor, Corresponding Member RAS, Head Laboratory of Molecular Diagnostics, Head of department of Molecular Vaccinology and Immunodiagnostics

Russian Federation, 123098, Moscow

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Copyright (c) 2022 Bakhrushina E.O., Mikhel J.B., Kondratieva V.M., Demina N.B., Grebennikova T.V.

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