Study of the prevalence of antibodies to some arboviruses in the population of the Republic of Guinea

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Abstract

Introduction. Acute febrile diseases kill more than 250,000 people annually in West Africa. Malaria and typhoid fever traditionally occupy most of the total structure of registered fevers. However, these data do not fully reflect the true overall disease patterns in the West African region. This is due to the fact that diagnosis is mainly based on the clinical signs of the infectious process, suggesting that a certain number of diseases may be caused by arboviruses. The detection of specific antibodies (ABs) to infectious pathogens in the blood sera of residents of a particular area is a reliable indicator of the circulation of these pathogens in a particular territory.

The aim of this study was to determine the prevalence of antibodies to a number of arboviruses: Dengue (DENV), West Nile (WNV) (family Flaviviridae), Crimean-Congo hemorrhagic fever (orthonairo)virus (CCHFV), Batai (Batai virus), Bhanja (BHAV) (order Bunyavirales), Chikungunya (CHIKV), and Sindbis (SINV) (family Togaviridae) in the population of the Republic of Guinea.

Material and methods. In total, a panel of 2,620 blood serum samples from people living in all landscape and geographical areas of Guinea was collected for the study. Detection of IgG antibodies was performed using an enzyme-linked immunoassay (ELISA).

Results. In total, ABs to Batai virus were detected in 144 samples (5.5%), BHAV in 58 (2.2%), WNV in 892 (34.0 %), DENV in 659 (25.2 %), CCHFV in 58 (2.2 %), CHIKV in 339 (12.9 %), and SINV in 52 samples (2.0 %).

Discussion. The obtained results indicate serological evidence of the spectrum of arboviruses in the population of all landscape and geographical zones of the Republic of Guinea, confirming their active circulation in this territory.

Conclusion. Given the high epidemiological significance of arbovirus infectious diseases, it is an urgent task to continue studying its share in the structure of febrile diseases in the territory of the Republic of Guinea.

About the authors

E. V. Naidenova

FSHI Russian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)

Author for correspondence.
Email: katim2003@mail.ru
ORCID iD: 0000-0001-6474-3696

Ekaterina V. Naidenova, Ph.D. (Biol.), Lead Researcher of the Virology Laboratory of the Infectious Diseases Diagnostic Department

410005, Saratov, Russia

Russian Federation

M. Yu. Kartashov

FSBI State Scientific Center of Virology and Biotechnology «Vector» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)

ORCID iD: 0000-0002-7857-6822

630559, Novosibirsk Region, Kol’tsovo, Russia

Russian Federation

K. S. Zakharov

FSHI Russian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)

ORCID iD: 0000-0002-4726-309X

410005, Saratov, Russia

Russian Federation

A. P. Shevtsova

FSHI Russian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)

ORCID iD: 0000-0001-9600-3801

410005, Saratov, Russia

Russian Federation

M. G. Diallo

Regional University of Kindia

ORCID iD: 0000-0003-4507-4575

Kindia, Republic of Guinea

Guinea

I. Nourdine

Research Institute of Applied Biology of Guinea

ORCID iD: 0000-0002-2970-9676

Kindia, Republic of Guinea

Guinea

M. B. Bah

Research Institute of Applied Biology of Guinea

ORCID iD: 0000-0002-4565-269X

Kindia, Republic of Guinea

Russian Federation

S. Boumbaly

Research Institute of Applied Biology of Guinea

ORCID iD: 0000-0002-4506-6033

Kindia, Republic of Guinea

Guinea

S. A. Shcherbakova

FSHI Russian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)

ORCID iD: 0000-0003-1143-4069

410005, Saratov, Russia

Russian Federation

V. V. Kutyrev

FSHI Russian Research Anti-Plague Institute «Microbe» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)

ORCID iD: 0000-0003-3788-3452

410005, Saratov, Russia

Russian Federation

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Copyright (c) 2021 Naidenova E.V., Kartashov M.Y., Zakharov K.S., Shevtsova A.P., Diallo M.G., Nourdine I., Bah M.B., Boumbaly S., Shcherbakova S.A., Kutyrev V.V.

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