Prospects for using low-dose radiation in the complex therapy for COVID-19

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Abstract

This review presents the literature data of new approaches for the treatment of COVID-19 with low doses of radiation (LDR). In addition, data on the use of LDR for the treatment of various disorders, in particular pneumonia, a number of inflammatory processes of various etiology, as well as Alzheimer’s disease are discussed. The mechanisms of LDR action are briefly described, associated with the activation of the immune system and antiinflammatory response due to the effect on the processes of oxidative stress, which is reflected in an increase in the activity of cytokines (interleukin- (IL-) 6), changes in the expression of a number of genes (such as P53 and NF-κB (p65)) and long non-coding RNAs (ncRNAs) (the authors’ own data are presented). Based on the analysis of the material presented, it can be assumed that further clinical trials of the effect of MDR (5–10 cGy) on patients with COVID-19, who are at different stages of the disease, will reveal the optimal conditions for the development and use of an effective treatment regimen.

About the authors

D. V. Saleeva

FSBI «State Research Center – Burnasyan Federal Medical Biophysical Center» of Federal Medical Biological Agency of Russia

Author for correspondence.
Email: dasha_saleeva@inbox.ru
ORCID iD: 0000-0002-5870-5594

Daria V. Saleeva, Junior Researcher of the Laboratory of Molecular Biology and Genetics of Radiation Effects.

123098, Moscow, Russia

Russian Federation

G. D. Zasukhina

FSBI «State Research Center – Burnasyan Federal Medical Biophysical Center» of Federal Medical Biological Agency of Russia; FSBIS Vavilov Institute of General Genetics of Russian Academy of Sciences

ORCID iD: 0000-0002-9871-0902

123098, Moscow, Russia

119991, Moscow, Russia

Russian Federation

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