Detection of potential sites of recombination in the Tick-borne encephalitis virus by the methods of comparative genomics
- 作者: Dzhioev Y.P.1,2, Paramonov A.1,2, Reva O.N.3, Bukin Y.S.4, Kozlova I.V.1,2, Demina T.V.5, Tkachev S.E.6, Zlobin V.I.1
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隶属关系:
- Irkutsk State Medical University, Ministry of Health of the Russian Federation
- Scientific Center of Family Health Problems and Human Reproduction, Siberian Branch, Russian Academy of Medical Sciences
- University of Pretoria
- Limnological Institute, Siberian Branch, Russian Academy of Sciences
- Irkutsk State Agricultural Academy
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
- 期: 卷 60, 编号 3 (2015)
- 页面: 44-49
- 栏目: ORIGINAL RESEARCH
- URL: https://journals.rcsi.science/0507-4088/article/view/118098
- ID: 118098
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详细
The results of the bioinformatic search for the potential sites of the recombination in the genome-wide structures of the tick-borne encephalitis virus (TBEV) through a series of software techniques were presented in this work. The genomes of the 55 TBEV strains were assayed, 21 of them showed the presence of the recombination sites. Recombinant strains belonged to the Far Eastern (19 strains) and European (2 strains) genotypes. 22 sites of the recombination attributed were identified to five types based on position, strain, and regional characteristics. The parental strains were identified based on the genotypic and geographical parameters, which do not contradict the possibility of the formation of the recombinants. Nearly two-thirds of the sites are located in the regions of NS4a and Ns4b genes, which are the "hot spots" of the recombination, most of them being concentrated in the gene NS4. it was shown that the recombination processes did not occur at the level of the genotypes (European genotype) or certain groups within the genotype (Far East) and were typical of the peripheral populations.
作者简介
Yu. Dzhioev
Irkutsk State Medical University, Ministry of Health of the Russian Federation; Scientific Center of Family Health Problems and Human Reproduction, Siberian Branch, Russian Academy of Medical Sciences
编辑信件的主要联系方式.
Email: alanir07@mail.ru
Yuriy Dzhioev, MD, PhD
664025, Irkutsk
664003, Irkutsk
俄罗斯联邦A. Paramonov
Irkutsk State Medical University, Ministry of Health of the Russian Federation; Scientific Center of Family Health Problems and Human Reproduction, Siberian Branch, Russian Academy of Medical Sciences
Email: fake@neicon.ru
664025, Irkutsk
664003, Irkutsk
俄罗斯联邦O. Reva
University of Pretoria
Email: fake@neicon.ru
南非
Yu. Bukin
Limnological Institute, Siberian Branch, Russian Academy of Sciences
Email: fake@neicon.ru
664082, Irkutsk 俄罗斯联邦
I. Kozlova
Irkutsk State Medical University, Ministry of Health of the Russian Federation; Scientific Center of Family Health Problems and Human Reproduction, Siberian Branch, Russian Academy of Medical Sciences
Email: fake@neicon.ru
664025, Irkutsk
664003, Irkutsk
俄罗斯联邦T. Demina
Irkutsk State Agricultural Academy
Email: fake@neicon.ru
664038,Irkutsk 俄罗斯联邦
S. Tkachev
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
Email: fake@neicon.ru
630090,Novosibirsk 俄罗斯联邦
V. Zlobin
Irkutsk State Medical University, Ministry of Health of the Russian Federation
Email: fake@neicon.ru
664025, Irkutsk 俄罗斯联邦
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