A comparative analysis of virucidal efficiency of biocide agents
- Authors: Nosik N.N.1, Nosik D.N.1, Chizhov A.I.1
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Affiliations:
- Federal State Budgetary Institution «Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
- Issue: Vol 62, No 1 (2017)
- Pages: 41-45
- Section: TO VIROLOGIST’S AID
- URL: https://journals.rcsi.science/0507-4088/article/view/117922
- DOI: https://doi.org/10.18821/0507-4088-2017-62-1-41-45
- ID: 117922
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Abstract
The main groups of biocide agents used for inactivation of bacteria and viruses were studied for their virucidal activity against enveloped (HIV, viral hepatitis C, influenza virus A) and non-enveloped viruses (poliovirus, adenovirus). Their efficiency was analyzed. Quarterly ammonium compounds (QAC) themselves are not able to properly inactivate non-enveloped viruses. However, they can be successfully applied in combination with other biocides (guanidines, aldehydes). Effective composition of QAC with amines and guanidines provided inactivation of viruses (4.0 lgTCID50) in concentrations of 0.166-0.280% for non-enveloped viruses and 0.080-00.185% for enveloped viruses. The combination of QAC with aldehydes is especially effective (0.04-0.64% for non-enveloped viruses). The virucidal efficiency does not directly depend on the QAC concentration in the chemical disinfectants.
About the authors
N. N. Nosik
Federal State Budgetary Institution «Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
Author for correspondence.
Email: nosiknn@yandex.ru
Russian Federation
D. N. Nosik
Federal State Budgetary Institution «Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
Email: noemail@neicon.ru
Russian Federation
A. I. Chizhov
Federal State Budgetary Institution «Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya»
Email: noemail@neicon.ru
Russian Federation
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