Metrological support for accurate measurements of the concentration of nitrosamines in food products: reference materials of the composition of nitrosamines and measurement procedures

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Accurate measurements of the content of nitrosamines in food products, pharmaceuticals, and water can guarantee the quality of these products and drinking water. In order to provide accurate measurement results to the population, it is necessary to have, and in the absence of, the creation of metrological support tools and methods that guarantee accurate measurement results. By the time work began on the creation of standard samples of nitrosamines in the field of food quality assurance, the validity period of previously created ones had expired many years ago, i.e. There were no metrological support facilities.This article is devoted to the topic of determining the content of nitrosamines in food products using measurement methods and reference samples and presents the issues of ensuring metrological traceability of nitrosamine measurement results. As a result of the work done, the content of nitrosamines in standard samples was determined, which will allow accurate measurement of the content of nitrosamines in food. The article consists of four interrelated parts and its purpose is to find answers to the tasks outlined above. The characteristics of the developed standard samples of the composition of N-nitrosodimethylamine (NDMA), the composition of N-dipropylnitrosamine (DPNA), the composition of N-nitrosodiethylamine (NDEA) and the certified measurement method are given. The results are relevant for the development and application of standard samples of the composition of nitrosamines, certification of measurement methods to meet the needs of the national economy. Methods and means of metrological support of measurements of nitrosamines in food products have been created.

About the authors

E. V. Kulyabina

Research Center for Applied Metrology – Rostest; MIREA – Russian Technological University

ORCID iD: 0000-0002-6076-4569

F. V. Bulygin

Research Center for Applied Metrology – Rostest

ORCID iD: 0000-0002-5026-9361

T. V. Kulyabina

Research Center for Applied Metrology – Rostest

ORCID iD: 0000-0003-3923-5571

O. N. Melkova

Research Center for Applied Metrology – Rostest

ORCID iD: 0000-0003-0580-1352

V. V. Morozova

Research Center for Applied Metrology – Rostest; California State University

Email: lerapuri@gmail.com
ORCID iD: 0000-0003-1251-5872

V. Yu. Morozov

Rusagro Group

Email: rexttd@mail.ru
ORCID iD: 0009-0009-8728-1039

M. V. Dorman

Research Center for Applied Metrology – Rostest

A. A. Kirilyuk

Research Center for Applied Metrology – Rostest

U. I. Sidorova

Research Center for Applied Metrology – Rostest

D. V. Kuznetsov

Volgograd Regional Clinical Narcological Dispensary

Email: danmbf@mail.ru

A. Z. Temerdashev

Kuban State University

Email: TemerdashevAZ@gmail.com
ORCID iD: 0000-0002-8048-4740

A. V. Ivanov

All-Russian Research Institute of Optical-Physical Measurements

Email: ivanov@vniiofi.ru

References

  1. Andrzejewski P., Kasprzyk-Hordern B., Nawrocki J. The hazard of N-nitrosodimethylamine (NDMA) formation during water disinfection with strong oxidants. Desalination, 176(1–3), 37–45 (2005). https://doi.org/10.1016/j.desal.2004.11.009 ; https://elibrary.ru/kekizr
  2. Collivignarelli M. C., Abbà A., Benigna I., Sorlini S., Torretta V. Overview of the main disinfection processes for wastewater and drinking water treatment plants. Sustainability, 10(1), 86 (2018). https://doi.org/10.3390/su10010086 ; https://elibrary.ru/yendjz
  3. Кулябина Е. В., Мелкова О. Н., Кулябина Т. В., Морозова В. В., Морозов В. Ю. Письмо редактору: Вопросы метрологического обеспечения измерений в сферах деятельности, способствующих повышению качества жизни человека. Альманах современной метрологии, (1(33)), 125–130 (2023) https://elibrary.ru/lpmodn
  4. Parr M. K., Joseph J. F. NDMA Impurity in Valsartan and other Pharmaceutical Products: Analytical Methods for the Determination of N-Nitrosamines. Journal of Pharmaceutical and Biomedical Analysis, 164, 536–549 (2019). https://doi.org/10.1016/j.jpba.2018.11.010 ; https://elibrary.ru/lrnero
  5. Aygün S. F., Uyanık A., Batı B. Adsorption of N-nitrosodiethylamine and N-nitrosodimethylamine on activated carbon: a pre-concentration procedure for gas chromatographic analysis. Microchimica Acta, 146, 279–283 (2004). https://doi.org/10.1007/s00604-004-0225-3 ; https://elibrary.ru/foxhpf
  6. Topuz E., Aydin E., Pehlivanoglu-Mantas E. A practical LC-MS/MS method for the detection of NDMA at nanogram per liter concentrations in multiple water matrices. Water, Air, & Soil Pollution, 223, 5793–5802 (2012). https://doi.org/10.1007/s11270-012-1315-1 ; https://elibrary.ru/ovdsmf
  7. Kodamatani H., Yamazaki S., Saito K., Tomiyasu T., Komatsu Y. Selective determination method for measurement of nitrite and nitrate in water samples using high-performance liquid chromatography with post-column photochemical reaction and chemiluminescence detection. Journal of Chromatography A, 1216(15), 3163–3167 (2009). https://doi.org/10.1016/j.chroma.2009.01.096 ; https://elibrary.ru/kpjkpp
  8. Ugwueze Chidiebere V., Ezeude Chidiebele M., Abonyi Chinweuba M., Nwatu Chidimma B., Ukwaja Kingsley N., Young Ekenechukwu E. N-Nitrosodimethylamine (NDMA) and Some Prescribed Medicines: A Mini-review. International Journal of Medicine and Health Development, 27(2), 109–113 (2022). https://doi.org/10.4103/ijmh.IJMH_15_21 ; https://elibrary.ru/ohlabi
  9. Ajith Kumar P. V., Deepa M. Metformin and nitrosamine impurities. International Journal of Research in Medical Sciences, 8(10), 3778–3784 (2020). https://doi.org/10.18203/2320-6012.ijrms20204273 ; https://elibrary.ru/zsesqh

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).