Circadian regulation and its disorders in Parkinson’s disease patients. Part 2: Experimental models, alpha-synuclein, and melatonin
- Authors: Ukraintseva Y.V.1, Kovalzon V.M.2
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Affiliations:
- Institute of Higher Nervous Activity and Neurophysiology
- Severtsov Institute of Ecology and Evolution
- Issue: Vol 42, No 5 (2016)
- Pages: 559-570
- Section: Reviews
- URL: https://journals.rcsi.science/0362-1197/article/view/176759
- DOI: https://doi.org/10.1134/S0362119716050170
- ID: 176759
Cite item
Abstract
Circadian disturbances related to Parkinson’s disease are reviewed, and possible pathogenetic mechanisms are discussed. The role of dopaminergic system degeneration in the development of circadian dysfunction is emphasized. The accumulation of α-synuclein in the suprachiasmatic nucleus is considered as a possible mechanism of circadian dysfunction unrelated to dopamine deficiency. Data on the disbalance of dopamine and melatonin levels in Parkinson’s disease patients and its role in disturbances of circadian rhythms of physiological processes are analyzed.
About the authors
Yu. V. Ukraintseva
Institute of Higher Nervous Activity and Neurophysiology
Author for correspondence.
Email: ukraintseva@yandex.ru
Russian Federation, Moscow
V. M. Kovalzon
Severtsov Institute of Ecology and Evolution
Email: ukraintseva@yandex.ru
Russian Federation, Moscow