Circadian regulation and its disorders in Parkinson’s disease patients. Part 2: Experimental models, alpha-synuclein, and melatonin
- 作者: Ukraintseva Y.1, Kovalzon V.2
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隶属关系:
- Institute of Higher Nervous Activity and Neurophysiology
- Severtsov Institute of Ecology and Evolution
- 期: 卷 42, 编号 5 (2016)
- 页面: 559-570
- 栏目: Reviews
- URL: https://journals.rcsi.science/0362-1197/article/view/176759
- DOI: https://doi.org/10.1134/S0362119716050170
- ID: 176759
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详细
Circadian disturbances related to Parkinson’s disease are reviewed, and possible pathogenetic mechanisms are discussed. The role of dopaminergic system degeneration in the development of circadian dysfunction is emphasized. The accumulation of α-synuclein in the suprachiasmatic nucleus is considered as a possible mechanism of circadian dysfunction unrelated to dopamine deficiency. Data on the disbalance of dopamine and melatonin levels in Parkinson’s disease patients and its role in disturbances of circadian rhythms of physiological processes are analyzed.
作者简介
Yu. Ukraintseva
Institute of Higher Nervous Activity and Neurophysiology
编辑信件的主要联系方式.
Email: ukraintseva@yandex.ru
俄罗斯联邦, Moscow
V. Kovalzon
Severtsov Institute of Ecology and Evolution
Email: ukraintseva@yandex.ru
俄罗斯联邦, Moscow