Changes in functional connectivity of motor zones in the course of treatment with a regent multimodal complex exoskeleton in neurorehabilitation of post-stroke patients
- Authors: Saenko I.V.1,2, Morozova S.N.3, Zmeykina E.A.3, Konovalov R.N.3, Chervyakov A.V.3, Poydasheva A.G.3, Chernikova L.A.3, Suponeva N.A.3, Piradov M.A.3, Kozlovskaya I.B.1
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Affiliations:
- Institute of Medico-Biological Problems
- Center of Aerospace Medicine
- Neurology Research Center
- Issue: Vol 42, No 1 (2016)
- Pages: 54-60
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/176536
- DOI: https://doi.org/10.1134/S036211971601014X
- ID: 176536
Cite item
Abstract
The effect of a treatment course with a Regent multimodal complex exoskeleton (MCE) on the reorganization of cortical locomotor zones was studied in 14 patients with post-stroke hemiparesis, mainly in the chronic stage of the disease. Specific activation zones were identified prior to treatment in the primary sensorimotor and supplementary motor areas and the inferior parietal lobules of both affected and healthy hemispheres by functional magnetic resonance imaging (fMRI) used in a special passive sensorimotor paradigm. After a treatment course with the MCE, temporal characteristics of walking were found to improve, which was accompanied by a decrease in the activation zones of the inferior parietal lobules, especially in the healthy hemisphere, and a significant increase in the activation zones of the primary sensorimotor and supplementary motor areas. Significant changes in intrahemispheric and interhemispheric interactions were revealed by analyzing the functional connectivity of the zones under study before and after a course of treatment with the MCE.
About the authors
I. V. Saenko
Institute of Medico-Biological Problems; Center of Aerospace Medicine
Author for correspondence.
Email: isayenko@mail.ru
Russian Federation, Moscow; Moscow
S. N. Morozova
Neurology Research Center
Email: isayenko@mail.ru
Russian Federation, Moscow
E. A. Zmeykina
Neurology Research Center
Email: isayenko@mail.ru
Russian Federation, Moscow
R. N. Konovalov
Neurology Research Center
Email: isayenko@mail.ru
Russian Federation, Moscow
A. V. Chervyakov
Neurology Research Center
Email: isayenko@mail.ru
Russian Federation, Moscow
A. G. Poydasheva
Neurology Research Center
Email: isayenko@mail.ru
Russian Federation, Moscow
L. A. Chernikova
Neurology Research Center
Email: isayenko@mail.ru
Russian Federation, Moscow
N. A. Suponeva
Neurology Research Center
Email: isayenko@mail.ru
Russian Federation, Moscow
M. A. Piradov
Neurology Research Center
Email: isayenko@mail.ru
Russian Federation, Moscow
I. B. Kozlovskaya
Institute of Medico-Biological Problems
Email: isayenko@mail.ru
Russian Federation, Moscow