Роль убиквитин-протеасомной системы в биологии стволовых клеток

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Аннотация

Селективная деградация клеточных белков с участием убиквитин-протеасомной системы является одним из ключевых регуляторных механизмов в эукариотических клетках. Накапливающиеся данные свидетельствуют о том, что убиквитин-протеасомная система участвует в регуляции фундаментальных процессов в стволовых клетках млекопитающих, включая пролиферацию, дифференцировку, миграцию, старение и программируемую гибель клеток. Регуляция может осуществляться либо путем протеолитической деградации ключевых транскрипционных факторов и белков сигнальных путей, либо путем посттрансляционных модификаций белков-мишеней убиквитином или другими убиквитинподобными модификаторами. Исследования молекулярных механизмов поддержания протеостаза в стволовых клетках имеют большое значение для разработки новых терапевтических подходов, направленных на лечение аутоиммунных, онкологических, нейродегенеративных и других социально-значимых патологий. Данный обзор охватывает актуальные данные о функции убиквитин-протеасомной системы в стволовых клетках.

Об авторах

А. В Буров

Институт молекулярной биологии им. В.А. Энгельгардта РАН

119991 Москва, Россия

А. А Родин

Институт молекулярной биологии им. В.А. Энгельгардта РАН

119991 Москва, Россия

В. Л Карпов

Институт молекулярной биологии им. В.А. Энгельгардта РАН

119991 Москва, Россия

А. В Морозов

Институт молекулярной биологии им. В.А. Энгельгардта РАН

Email: runkel@inbox.ru
119991 Москва, Россия

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