BIological and Pathophysiological Significance of De Novo Ceramide Biosynthesis Enzymes

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Abstract

Abstract—Ceramides are biologically active lipids with a wide range of effects that act as a second messenger in adipose tissue (AT) that regulates the metabolic homeostasis of the whole organism [83]. At least 3 ceramide synthesis pathways are known: de novo, sphingomyelinase, and the recycling/“rescue” pathway [47]. This review summarizes data on the physiological and pathophysiological effects of de novo ceramide biosynthesis enzymes.

About the authors

E. V. Belik

Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases

Author for correspondence.
Email: sionina.ev@mail.ru
Russia, 650002, Kemerovo

Yu. A. Dyleva

Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases

Author for correspondence.
Email: dyleva87@yandex.ru
Russia, 650002, Kemerovo

O. V. Gruzdeva

Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases; Federal State Budgetary Educational Institution of Higher Education “Kemerovo State Medical University”
of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: o_gruzdeva@mail.ru
Russia, 650002, Kemerovo; Russia, 650056, Kemerovo

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