The Social Anhedonia: (f)MRI Studies

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Abstract—Anhedonia and, particularly, social anhedonia is an important psychiatric symptom playing a crucial role in the development of depression and schizophrenia. Social anhedonia in healthy people is related to changes in structure, activation, and connectivity of different regions in the prefrontal, temporal, parieto-temporal, and basal areas. In patients with schizophrenia the core fMRI correlates of social anhedonia are located in the temporal lobe. Studies in social anhedonia in depressions and other mental disorders are insufficient for drawing conclusions on this topic. Unlike physical anhedonia, social anhedonia demonstrates no specific link with the Nucleus accumbens volume or activation.

About the authors

M. Ye. Melnikov

Federal Research Center of Fundamental and Translational Medicine, Institute of Molecular Biology and Biophysics

Author for correspondence.
Email: mikhail-melnikov@mail.ru
Russia, 630117, Novosibirsk

References

  1. Аведисова А.С., Захарова К.В., Гаскин В.В. и др. Клинические и нейровизуализационные характеристики апатической депрессии // Журн. неврологии и психиатрии. 2017. Т. 117. № 8. С. 11–17. https://doi.org/10.17116/jnevro20171178111-17
  2. Abraham E., Wang Y., Svob C. et al. Organization of the social cognition network predicts future depression and interpersonal impairment: a prospective family-based study // Neuropsychopharmacology. 2022. V. 47. № 2. P. 531–542. https://doi.org/10.1038/s41386-021-01065-8
  3. Alacreu-Crespo A., Olié E., Le Bars E. et al. Prefrontal activation in suicide attempters during decision making with emotional feedback // Translational Psychiatry. 2020. V. 10. № 1. e313. https://doi.org/10.1038/s41398-020-00995-z
  4. Bang M., Kang J.I., Kim S.J. et al. Reduced DNA Methylation of the Oxytocin Receptor Gene Is Associated With Anhedonia-Asociality in Women With Recent-Onset Schizophrenia and Ultra-high Risk for Psychosis // Schizophrenia Bulletin. 2019. V. 45. № 6. P. 1279–1290. https://doi.org/10.1093/schbul/sbz016
  5. Borsini A., Wallis A.J., Zunszain P. et al. Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression // Cognitive, Affective, & Behavioral Neuroscience. 2020. V. 20. № 4. P. 816–841. https://doi.org/10.3758/s13415-020-00804-6
  6. Bracht T., Linden D., Keedwell P. A review of white matter microstructure alterations of pathways of the reward circuit in depression // J. Affective Disorders. 2015. V. 187. P. 45–53. https://doi.org/10.1016/j.jad.2015.06.041
  7. Bradley K.A., Alonso C.M., Mehra L.M. et al. Elevated striatal γ-aminobutyric acid in youth with major depressive disorder // Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2018. V. 86. P. 203–210. https://doi.org/10.1016/j.pnpbp.2018.06.004
  8. Brakowski J., Manoliu A., Homan P. et al. Aberrant striatal coupling with default mode and central executive network relates to self-reported avolition and anhedonia in schizophrenia // J. Psychiatric Research. 2022. V. 145. P. 263–275. https://doi.org/10.1016/j.jpsychires.2020.10.047
  9. Brandt I.M., Köhler-Forsberg K., Ganz M. et al. Reward processing in major depressive disorder and prediction of treatment response – Neuropharm study // European Neuropsychopharmacology. 2021. V. 44. P. 23–33. https://doi.org/10.1016/j.euroneuro.2020.12.010
  10. Brown V.M., Zhu L., Solway A. et al. Reinforcement Learning Disruptions in Individuals With Depression and Sensitivity to Symptom Change Following Cognitive Behavioral Therapy // JAMA Psychiatry. 2021. V. 78. № 10. P. 1113–1122. https://doi.org/10.1001/jamapsychiatry.2021.1844
  11. Burklund L.J., Craske M.G., Taylor S.E., Lieberman M.D. Altered emotion regulation capacity in social phobia as a function of comorbidity // Social Cognitive & Affective Neuroscience. 2015. V. 10. № 2. P. 199–208. https://doi.org/10.1093/scan/nsu058
  12. Cáceda R., James G.A., Stowe Z.N. et al. The neural correlates of low social integration as a risk factor for suicide // European Archives of Psychiatry and Clinical Neuroscience. 2020. V. 270. № 5. P. 619–631. https://doi.org/10.1007/s00406-019-00990-6
  13. Casement M.D., Guyer A.E., Hipwell A.E. et al. Girls’ challenging social experiences in early adolescence predict neural response to rewards and depressive symptoms // Developmental Cognitive Neuroscience. 2014. V. 8. P. 18–27. https://doi.org/10.1016/j.dcn.2013.12.003
  14. Cernasov P., Walsh E.C., Kinard J.L. et al. Multilevel growth curve analyses of behavioral activation for anhedonia (BATA) and mindfulness-based cognitive therapy effects on anhedonia and resting-state functional connectivity: Interim results of a randomized trial // Journal of Affective Disorders. 2021. V. 292. P. 161–171. https://doi.org/10.1016/j.jad.2021.05.054
  15. Chanel G., Pichon S., Conty L. et al. Classification of autistic individuals and controls using cross-task characterization of fMRI activity // Neuroimage: Clinical. 2015. V. 10. P. 78–88. https://doi.org/10.1016/j.nicl.2015.11.010
  16. Chiapponi C., Piras F., Piras F. et al. GABA System in Schizophrenia and Mood Disorders: A Mini Review on Third-Generation Imaging Studies // Frontiers in Psychiatry. 2016. V. 7. e61. https://doi.org/10.3389/fpsyt.2016.00061
  17. Choi S.-H., Lee H., Ku J. et al. Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia // World J. Biological Psychiatry. 2014. V. 15. № 7. P. 525–533. https://doi.org/10.3109/15622975.2013.819121
  18. Costi S., Morris L.S., Collins A. et al. Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia // Translational Psychiatry. 2021. V. 11. № 1. e565. https://doi.org/10.1038/s41398-021-01668-1
  19. Cressman V.L., Schobel S.A., Steinfeld S. et al. Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity // NPJ Schizophrenia. 2015. V. 1. e15020. https://doi.org/10.1038/npjschz.2015.20
  20. Cusi A.M., Nazarov A., Holshausen K. et al. Systematic review of the neural basis of social cognition in patients with mood disorders // J. Psychiatry & Neuroscience. 2012. V. 37. № 3. P. 154–169. https://doi.org/10.1503/jpn.100179
  21. Dennison M.J., Sheridan M.A., Busso D.S. et al. Neurobehavioral markers of resilience to depression amongst adolescents exposed to child abuse // J. Abnormal Psychology. 2016. V. 125. № 8. P. 1201–1212. https://doi.org/10.1037/abn0000215
  22. Derntl B., Seidel E.-M., Eickhoff S.B. et al. Neural correlates of social approach and withdrawal in patients with major depression // Social Neuroscience. 2011. V. 6. № 5–6. P. 482–501. https://doi.org/10.1080/17470919.2011.579800
  23. Diaz A.P., Fernandes B.S., Teixeira A.L. et al. White matter microstructure associated with anhedonia among individuals with bipolar disorders and high-risk for bipolar disorders // J. Affective Disorders. 2022. V. 300. P. 91–98. https://doi.org/10.1016/j.jad.2021.12.037
  24. Diederichs C., DeMayo M.M., Cole J. et al. Intermittent Theta-Burst Stimulation Transcranial Magnetic Stimulation Increases GABA in the Medial Prefrontal Cortex: A Preliminary Sham-Controlled Magnetic Resonance Spectroscopy Study in Acute Bipolar Depression // Frontiers in Psychiatry. 2021. V. 12. e665402. https://doi.org/10.3389/fpsyt.2021.665402
  25. Dodell-Feder D., Tully L.M., Lincoln S.H., Hooker C.I. The neural basis of theory of mind and its relationship to social functioning and social anhedonia in individuals with schizophrenia // Neuroimage: Clinical. 2013. V. 4. P. 154–163. https://doi.org/10.1016/j.nicl.2013.11.006
  26. Domschke K., Dannlowski U., Ohrmann P. et al. Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression // European Neuropsychopharmacology. 2008. V. 18. № 10. P. 751–759. https://doi.org/10.1016/j.euroneuro.2008.05.003
  27. Dotson V.M., Taiwo Z., Minto L.R. et al. Orbitofrontal and Cingulate Thickness Asymmetry Associated with Depressive Symptom Dimensions // Cognitive, Affective, & Behavioral Neuroscience. 2021. V. 21. № 6. P. 1297–1305. https://doi.org/10.3758/s13415-021-00923-8
  28. Dowd E.C., Barch D.M. Pavlovian reward prediction and receipt in schizophrenia: relationship to anhedonia // PLoS One. 2012. V. 7. № 5. e35622. https://doi.org/10.1371/journal.pone.0035622
  29. Dowd E.C., Frank M.J., Collins A. et al. Probabilistic Reinforcement Learning in Patients With Schizophrenia: Relationships to Anhedonia and Avolition // Biological Psychiatry: Cognitive Neuroscience & Neuroimaging. 2016. V. 1. № 5. P. 460–473. https://doi.org/10.1016/j.bpsc.2016.05.005
  30. Du H., Xia J., Fan J. et al. Spontaneous neural activity in the right fusiform gyrus and putamen is associated with consummatory anhedonia in obsessive compulsive disorder // Brain Imaging & Behavior. In print. https://doi.org/10.1007/s11682-021-00619-0
  31. Duprat R., Wu G.-R., De Raedt R., Baeken C. Accelerated iTBS treatment in depressed patients differentially modulates reward system activity based on anhedonia // World Journal of Biological Psychiatry. 2018. V. 19. № 7. P. 497–508. https://doi.org/10.1080/15622975.2017.1355472
  32. Eckstrand K.L., Flores Jr. L.E., Cross M. et al. Social and Non-social Reward Processing and Depressive Symptoms Among Sexual Minority Adolescents // Frontiers in Behavioral Neuroscience. 2019. V. 13. e209. https://doi.org/10.3389/fnbeh.2019.00209
  33. Eckstrand K.L., Forbes E.E., Bertocci M.A. et al. Anhedonia Reduction and the Association Between Left Ventral Striatal Reward Response and 6-Month Improvement in Life Satisfaction Among Young Adults // JAMA Psychiatry. 2019. V. 76. № 9. P. 958–965. https://doi.org/10.1001/jamapsychiatry.2019.0864
  34. Ely B.A., Nguyen T.N.B., Tobe R.H. et al. Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression // Frontiers in Psychiatry. 2021. V. 12. e678709. https://doi.org/10.3389/fpsyt.2021.678709
  35. Enneking V., Krüssel P., Zaremba D. et al. Social anhedonia in major depressive disorder: a symptom-specific neuroimaging approach // Neuropsychopharmacology. 2019. V. 44. № 5. P. 883–889. https://doi.org/10.1038/s41386-018-0283-6
  36. Fani N., Michopoulos V., van Rooij S.J.H. et al. Structural connectivity and risk for anhedonia after trauma: A prospective study and replication // Journal of Psychiatric Research. 2019. V. 116. P. 34–41. https://doi.org/10.1016/j.jpsychires.2019.05.009
  37. Ferenczi E.A., Zalocusky K.A., Liston C. et al. Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior // Science. 2016. V. 351. № 6268. aac9698. https://doi.org/10.1126/science.aac9698
  38. Frewen P.A., Dozois D.J.A., Lanius R.A. Assessment of anhedonia in psychological trauma: psychometric and neuroimaging perspectives // European J. Psychotraumatology. 2012. e3. https://doi.org/10.3402/ejpt.v3i0.8587
  39. Frey A.-L., McCabe C. Effects of serotonin and dopamine depletion on neural prediction computations during social learning // Neuropsychopharmacology. 2020. V. 45. № 9. P. 1431–1437. https://doi.org/10.1038/s41386-020-0678-z
  40. Frey A.-L., McCabe C. Impaired social learning predicts reduced real-life motivation in individuals with depression: A computational fMRI study // J. Affective Disorders. 2020. V. 263. P. 698–706. https://doi.org/10.1016/j.jad.2019.11.049
  41. Fusar-Poli P., Placentino A., Carletti F. et al. Functional atlas of emotional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies // J. Psychiatry & Neuroscience. 2009. V. 34. № 6. P. 418–432.
  42. Gabbay V., Bradley K.A., Mao X. et al. Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression // Translational Psychiatry. 2017. V. 7. № 8. e1216. https://doi.org/10.1038/tp.2017.187
  43. Gabbay V., Mao X., Klein R.G. et al. Anterior cingulate cortex γ-aminobutyric acid in depressed adolescents: relationship to anhedonia // Archives of General Psychiatry. 2012. V. 69. № 2. P. 139–149. https://doi.org/10.1001/archgenpsychiatry.2011.131
  44. Geller W.N., Liu K., Warren S.L. Specificity of anhedonic alterations in resting-state network connectivity and structure: A transdiagnostic approach // Psychiatry Research: Neuroimaging. 2021. V. 317. e111349. https://doi.org/10.1016/j.pscychresns.2021.111349
  45. Germine L.T., Garrido L., Bruce L., Hooker C. Social anhedonia is associated with neural abnormalities during face emotion processing // Neuroimage. 2011. V. 58. № 3. P. 935–945. https://doi.org/10.1016/j.neuroimage.2011.06.059
  46. Geugies H., Mocking R.J.T., Figueroa C.A. et al. Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression // Brain. 2019. V. 142. № 8. P. 2510–2522. https://doi.org/10.1093/brain/awz167
  47. Gong L., He C., Zhang H. et al. Disrupted reward and cognitive control networks contribute to anhedonia in depression // J. Psychiatric Research. 2018. V. 103. P. 61–68. https://doi.org/10.1016/j.jpsychires.2018.05.010
  48. Gradin V.B., Pérez A., MacFarlane J.A. et al. Abnormal brain responses to social fairness in depression: an fMRI study using the Ultimatum Game // Psychological Medicine. 2015. V. 45. № 6. P. 1241–1251. https://doi.org/10.1017/S0033291714002347
  49. Gradin V.B., Pérez A., MacFarlane J.A. et al. Neural correlates of social exchanges during the Prisoner’s Dilemma game in depression // Psychological Medicine. 2016. V. 46. № 6. P. 1289–1300. https://doi.org/10.1017/S0033291715002834
  50. Greening S.G., Osuch E.A., Williamson P.C., Mitchell D.G.V. Emotion-related brain activity to conflicting socio-emotional cues in unmedicated depression // Journal of Affective Disorders. 2013. V. 150. № 3. P. 1136–1141. https://doi.org/10.1016/j.jad.2013.05.053
  51. Groschwitz R.C., Plener P.L., Groen G. et al. Differential neural processing of social exclusion in adolescents with non-suicidal self-injury: An fMRI study // Psychiatry Research: Neuroimaging. 2016. V. 255. P. 43–49. https://doi.org/10.1016/j.pscychresns.2016.08.001
  52. Guffanti G., Kumar P., Admon R. et al. Depression genetic risk score is associated with anhedonia-related markers across units of analysis // Translational Psychiatry. 2019. V. 9. № 1. e236. https://doi.org/10.1038/s41398-019-0566-7
  53. Günther V., Lindner C., Dannlowski U. et al. Amygdalar Gray Matter Volume and Social Relating in Schizophrenia // Neuropsychobiology. 2016. V. 74. № 3. P. 139–143. https://doi.org/10.1159/000458528
  54. Günther V., Zimmer J., Kersting A. et al. Automatic processing of emotional facial expressions as a function of social anhedonia // Psychiatry Research: Neuroimaging. 2017. V. 270. P. 46–53. https://doi.org/10.1016/j.pscychresns.2017.10.002
  55. Han S., Cui Q., Wang X. et al. The anhedonia is differently modulated by structural covariance network of NAc in bipolar disorder and major depressive disorder // Progress in Neuropsychopharmacology & Biological Psychiatry. 2020. V. 99. e109865. https://doi.org/10.1016/j.pnpbp.2020.109865
  56. Hao L., Yang J., Wang Y. et al. Neural correlates of causal attribution in negative events of depressed patients: Evidence from an fMRI study // Clinical Neurophysiology. 2015. V. 126. № 7. P. 1331–1337. https://doi.org/10.1016/j.clinph.2014.10.146
  57. Harnett N.G., Stevens J.S., van Rooij S.J.H. et al. Multimodal structural neuroimaging markers of risk and recovery from posttrauma anhedonia: A prospective investigation // Depression & Anxiety. 2021. V. 38. № 1. P. 79–88. https://doi.org/10.1002/da.23104
  58. Harvey P.-O., Pruessner J., Czechowska Y., Lepage M. Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects // Molecular Psychiatry. 2007. V. 12. № 8. P. 767–775. https://doi.org/10.1038/sj.mp.4002021
  59. Healey K.L., Morgan J., Musselman S.C. et al. Social anhedonia and medial prefrontal response to mutual liking in late adolescents // Brain & Cognition. 2014. V. 89. P. 39–50. https://doi.org/10.1016/j.bandc.2013.12.004
  60. Hooker C.I., Benson T.L., Gyurak A. et al. Neural activity to positive expressions predicts daily experience of schizophrenia-spectrum symptoms in adults with high social anhedonia // J. Abnormal Psychology. 2014. V. 123. № 1. P. 190–204. https://doi.org/10.1037/a0035223
  61. Keedwell P.A., Andrew C., Williams S.C.R. et al. The neural correlates of anhedonia in major depressive disorder // Biological Psychiatry. 2005. V. 58. № 11. P. 843–853. https://doi.org/10.1016/j.biopsych.2005.05.019
  62. Keedwell P.A., Chapman R., Christiansen K. et al. Cingulum white matter in young women at risk of depression: the effect of family history and anhedonia // Biological Psychiatry. 2012. V. 72. P. 296–302. https://doi.org/10.1016/j.biopsych.2012.01.022
  63. Keller J., Young C.B., Kelley E. et al. Trait anhedonia is associated with reduced reactivity and connectivity of mesolimbic and paralimbic reward pathways // J. Psychiatric Research. 2013. V. 47. № 10. P. 1319–1328. https://doi.org/10.1016/j.jpsychires.2013.05.015
  64. Kim B.-H., Kim H.E., Lee J.S., Kim J.-J. Anhedonia Relates to the Altered Global and Local Grey Matter Network Properties in Schizophrenia // J. Clinical Medicine. 2021. V. 10. № 7. e1395. https://doi.org/10.3390/jcm10071395
  65. Kim K., Johnson M.K. Activity in ventromedial prefrontal cortex during self-related processing: positive subjective value or personal significance? // Social Cognitive & Affective Neuroscience. 2015. V. 10. № 4. P. 494–500. https://doi.org/10.1093/scan/nsu078
  66. Kini P., Wong J., McInnis S. et al. The effects of gratitude expression on neural activity // Neuroimage. 2016. V. 128. P. 1–10. https://doi.org/10.1016/j.neuroimage.2015.12.040
  67. Kirschner M., Schmidt A., Hodzic-Santor B. et al. Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum // Schizophrenia Bulletin. 2021. V. 47. № 3. P. 849–863. https://doi.org/10.1093/schbul/sbaa169
  68. Koeppel C.J., Herrmann T., Weidner K. et al. Same salience, different consequences: Disturbed inter-network connectivity during a social oddball paradigm in major depressive disorder // Neuroimage: Clinical. 2021. V. 31. e102731. https://doi.org/10.1016/j.nicl.2021.102731
  69. Krohne L.G., Wang Y., Hinrich J.L. et al. Classification of social anhedonia using temporal and spatial network features from a social cognition fMRI task // Human Brain Mapping. 2019. V. 40. № 17. P. 4965–4981. https://doi.org/10.1002/hbm.24751
  70. Krystal A.D., Pizzagalli D.A., Smoski M. et al. A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia // Nature Medicine. 2020. V. 26. № 5. P. 760–768. https://doi.org/10.1038/s41591-020-0806-7
  71. Kujawa A., Burkhouse K.L. Vulnerability to Depression in Youth: Advances from Affective Neuroscience // Biological Psychiatry: Cognitive Neuroscience & Neuroimaging. 2017. V. 2. № 1. P. 28–37. https://doi.org/10.1016/j.bpsc.2016.09.006
  72. Kumar P., Goer F., Murray L. et al. Impaired reward prediction error encoding and striatal-midbrain connectivity in depression // Neuropsychopharmacology. 2018. V. 43. № 7. P. 1581–1588. https://doi.org/10.1038/s41386-018-0032-x
  73. Kumari V., Peters E., Guinn A. et al. Mapping Depression in Schizophrenia: A Functional Magnetic Resonance Imaging Study // Schizophrenia Bulletin. 2016. V. 42. № 3. P. 802–813. https://doi.org/10.1093/schbul/sbv186
  74. Lamers A., Toepper M., Fernando S.C. et al. Caudate hyperactivation during the processing of happy faces in borderline personality disorder // Neuropsychologia. 2021. V. 163. e108086. https://doi.org/10.1016/j.neuropsychologia.2021.108086
  75. Lee H.-S., Lee J.-E., Lee K.-U., Kim Y.-H. Neural changes associated with emotion processing in children experiencing peer rejection: a functional MRI study // J. Korean Medical Science. 2014. V. 29. № 9. P. 1293–1300. https://doi.org/10.3346/jkms.2014.29.9.1293
  76. Lee J.S., Han K., Lee S.-K. et al. Altered structural connectivity and trait anhedonia in patients with schizophrenia // Neuroscience Letters. 2014. V. 579. P. 7–11. https://doi.org/10.1016/j.neulet.2014.07.001
  77. Lee J.S., Kim E.S., Kim E.J. et al. The relationship between self-referential processing-related brain activity and anhedonia in patients with schizophrenia // Psychiatry Research: Neuroimaging. 2016. V. 254. P. 112–118. https://doi.org/10.1016/j.pscychresns.2016.06.010
  78. Lee J.S., Park H.-J., Chun J.W. et al. Neuroanatomical correlates of trait anhedonia in patients with schizophrenia: a voxel-based morphometric study // Neuroscience Letters. 2011. V. 489. № 2. P. 110–114. https://doi.org/10.1016/j.neulet.2010.11.076
  79. Li G., Cao C., Fang R. et al. Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions // J. Psychiatric Research. 2021. V. 140. P. 30–34. https://doi.org/10.1016/j.jpsychires.2021.05.061
  80. Li X., Li Z., Li K. et al. The neural transfer effect of working memory training to enhance hedonic processing in individuals with social anhedonia // Scientific Reports. 2016. V. 6. e35481. https://doi.org/10.1038/srep35481
  81. Li Z., Zhang C.-Y., Huang J. et al. Improving motivation through real-time fMRI-based self-regulation of the nucleus accumbens // Neuropsychology. 2018. V. 32. № 6. P. 764–776. https://doi.org/10.1037/neu0000425
  82. Liu R., Wang Y., Chen X. et al. Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder // Neuroimage: Clinical. 2021. V. 30. e102599. https://doi.org/10.1016/j.nicl.2021.102599
  83. Liu X., Li L., Li M. et al. Characterizing the subtype of anhedonia in major depressive disorder: A symptom-specific multimodal MRI study // Psychiatry Research: Neuroimaging. 2021. V. 308. e111239. https://doi.org/10.1016/j.pscychresns.2020.111239
  84. MacNamara A., Klumpp H., Kennedy A.E. et al. Transdiagnostic neural correlates of affective face processing in anxiety and depression // Depression & Anxiety. 2017. V. 34. № 7. P. 621–631. https://doi.org/10.1002/da.22631
  85. Macoveanu J., Meluken I., Chase H.W. et al. Reduced frontostriatal response to expected value and reward prediction error in remitted monozygotic twins with mood disorders and their unaffected high-risk co-twins // Psychological Medicine. 2021. V. 51. № 10. P. 1637–1646. https://doi.org/10.1017/S0033291720000367
  86. Malejko K., Neff D., Brown R. et al. Neural Correlates of Social Inclusion in Borderline Personality Disorder // Frontiers in Psychiatry. 2018. V. 9. e653. https://doi.org/10.3389/fpsyt.2018.00653
  87. Matsunaga M., Kawamichi H., Umemura T. et al. Neural and Genetic Correlates of the Social Sharing of Happiness // Frontiers in Neuroscience. 2017. V. 11. e718. https://doi.org/10.3389/fnins.2017.00718
  88. Mellem M.S., Liu Y., Gonzalez H. et al. Machine Learning Models Identify Multimodal Measurements Highly Predictive of Transdiagnostic Symptom Severity for Mood, Anhedonia, and Anxiety // Biological Psychiatry: Cognitive Neuroscience & Neuroimaging. 2020. V. 5. № 1. P. 56–67. https://doi.org/10.1016/j.bpsc.2019.07.007
  89. Mies G.W., Van den Berg I., Franken I.H.A. et al. Neurophysiological correlates of anhedonia in feedback processing // Frontiers in Human Neuroscience. 2013. V. 7. e96. https://doi.org/10.3389/fnhum.2013.00096
  90. Mirabito G., Taiwo Z., Bezdek M., Light S.N. Fronto-striatal activity predicts anhedonia and positive empathy subtypes // Brain Imaging & Behavior. 2019. V. 13. № 6. P. 1554–1565. https://doi.org/10.1007/s11682-019-00081-z
  91. Mitterschiffthaler M.T., Kumari V., Malhi G.S. et al. Neural response to pleasant stimuli in anhedonia: an fMRI study // Neuroreport. 2003. V. 14. № 2. P. 177–182. https://doi.org/10.1097/00001756-200302100-00003
  92. Morgan J.K., Silk J.S., Woods B.K., Forbes E.E. Differential neural responding to affective stimuli in 6- to 8-year old children at high familial risk for depression: Associations with behavioral reward seeking // J. Affective Disorders. 2019. V. 257. P. 445–453. https://doi.org/10.1016/j.jad.2019.06.058
  93. Park I.H., Chun J.W., Park H.-J. et al. Altered cingulo-striatal function underlies reward drive deficits in schizophrenia // Schizophrenia Research. 2015. V. 161. № 2–3. P. 229–236. https://doi.org/10.1016/j.schres.2014.11.005
  94. Pelletier-Baldelli A., Orr J.M., Bernard J.A., Mittal V.A. Social reward processing: A biomarker for predicting psychosis risk? // Schizophrenia Research. 2020. V. 226. P. 129–137. https://doi.org/10.1016/j.schres.2018.07.042
  95. Perini I., Gustafsson P.A., Hamilton J.P. et al. Brain-based Classification of Negative Social Bias in Adolescents With Nonsuicidal Self-injury: Findings From Simulated Online Social Interaction // EClinicalMedicine. 2019. V. 13. P. 81–90. https://doi.org/10.1016/j.eclinm.2019.06.016
  96. Pessin S., Philippi C.L., Reyna L. et al. Influence of anhedonic symptom severity on reward circuit connectivity in PTSD // Behavioral Brain Research. 2021. V. 407. e113258. https://doi.org/10.1016/j.bbr.2021.113258
  97. Pfarr J.-K., Brosch K., Meller T. et al. Brain structural connectivity, anhedonia, and phenotypes of major depressive disorder: A structural equation model approach // Human Brain Mapping. 2021. V. 42. № 15. P. 5063–5074. https://doi.org/10.1002/hbm.25600
  98. Pisoni A., Davis S.W., Smoski M. Neural signatures of saliency-mapping in anhedonia: A narrative review // Psychiatry Research. 2021. V. 304. e114123. https://doi.org/10.1016/j.psychres.2021.114123
  99. Pulcu E., Lythe K., Elliott R. et al. Increased amygdala response to shame in remitted major depressive disorder // PLoS One. 2014. V. 9. № 1. e86900. .https://doi.org/10.1371/journal.pone.0086900
  100. Quarmley M.E., Nelson B.D., Clarkson T. et al. I Knew You Weren’t Going to Like Me! Neural Response to Accurately Predicting Rejection Is Associated With Anxiety and Depression // Frontiers in Behavioral Neuroscience. 2019. V. 13. e219. https://doi.org/10.3389/fnbeh.2019.00219
  101. Regenbogen C., Kellermann T., Seubert J. et al. Neural responses to dynamic multimodal stimuli and pathology-specific impairments of social cognition in schizophrenia and depression // British J. Psychiatry. 2015. V. 206. № 3. P. 198–205. https://doi.org/10.1192/bjp.bp.113.143040
  102. Rütgen M., Pfabigan D.M., Tik M. et al. Detached empathic experience of others' pain in remitted states of depression – An fMRI study // Neuroimage: Clinical. 2021. V. 31. e102699. https://doi.org/10.1016/j.nicl.2021.102699
  103. Ryan J., Pouliot J.J., Hajcak G., Nee D.E. Manipulating Reward Sensitivity Using Reward Circuit-Targeted Transcranial Magnetic Stimulation // Biological Psychiatry: Cognitive Neuroscience & Neuroimaging. 2022. S2451-9022(22)00050-7. https://doi.org/10.1016/j.bpsc.2022.02.011
  104. Rzepa E., McCabe C. Anhedonia and depression severity dissociated by dmPFC resting-state functional connectivity in adolescents // J. Psychopharmacology. 2018. V. 32. № 10. P. 1067–1074. https://doi.org/10.1177/0269881118799935
  105. Sankar A., Yttredahl A.A., Fourcade E.W. et al. Dissociable Neural Responses to Monetary and Social Gain and Loss in Women With Major Depressive Disorder // Frontiers in Behavioral Neuroscience. 2019. V. 13. e149. https://doi.org/10.3389/fnbeh.2019.00149
  106. Schaefer H.S., Putnam K.M., Benca R.M., Davidson R.J. Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression // Biological Psychiatry. 2006. V. 60. № 9. P. 974–986. https://doi.org/10.1016/j.biopsych.2006.03.024
  107. Schaub A.-C., Kirschner M., Schweinfurth N. et al. Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis // Neuroimage: Clinical. 2021. V. 32. e102825. https://doi.org/10.1016/j.nicl.2021.102825
  108. Schilbach L., Müller V.I., Hoffstaedter F. et al. Meta-analytically informed network analysis of resting state FMRI reveals hyperconnectivity in an introspective socio-affective network in depression // PLoS One. 2014. V. 9. № 4. e94973. https://doi.org/10.1371/journal.pone.0094973
  109. Schwartz K.T.G., Kryza–Lacombe M., Liuzzi M.T. et al. Social and Non-social Reward: A Preliminary Examination of Clinical Improvement and Neural Reactivity in Adolescents Treated With Behavioral Therapy for Anxiety and Depression // Frontiers in Behavioral Neuroscience. 2019. V. 13. e177. https://doi.org/10.3389/fnbeh.2019.00177
  110. Schwarz K., Moessnang C., Schweiger J.I. et al. Transdiagnostic Prediction of Affective, Cognitive, and Social Function Through Brain Reward Anticipation in Schizophrenia, Bipolar Disorder, Major Depression, and Autism Spectrum Diagnoses // Schizophrenia Bulletin. 2020. V. 46. № 3. P. 592–602. https://doi.org/10.1093/schbul/sbz075
  111. Seidel E.-M., Satterthwaite T.D., Eickhoff S.B. et al. Neural correlates of depressive realism – an fMRI study on causal attribution in depression // J. Affective Disorders. 2012. V. 138. № 3. P. 268–276. https://doi.org/10.1016/j.jad.2012.01.041
  112. Sharma A., Satterthwaite T.D., Vandekar L. et al. Divergent relationship of depression severity to social reward responses among patients with bipolar versus unipolar depression // Psychiatry Research: Neuroimaging. 2016. V. 254. P. 18–25. https://doi.org/10.1016/j.pscychresns.2016.06.003
  113. Shimada K., Kasaba R., Fujisawa T.X. et al. Subclinical maternal depressive symptoms modulate right inferior frontal response to inferring affective mental states of adults but not of infants // J. Affective Disorders. 2018. V. 229. P. 32–40. https://doi.org/10.1016/j.jad.2017.12.031
  114. Smith E.E., Cavanagh J.F., Allen J.J.B. Intracranial source activity (eLORETA) related to scalp-level asymmetry scores and depression status // Psychophysiology. 2018. V. 55. № 1. . https://doi.org/10.1111/psyp.13019
  115. Stein D.J. Depression, anhedonia, and psychomotor symptoms: the role of dopaminergic neurocircuitry // CNS Spectrum. 2008. V. 13. № 7. P. 561–565. https://doi.org/10.1017/s1092852900016837
  116. Stretton J., Walsh N.D., Mobbs D. et al. How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence // Brain & Behavior. 2021. V. 11. № 5. e02005. https://doi.org/10.1002/brb3.2005
  117. Suffel A., Nagels A., Steines M. et al. Feeling addressed! The neural processing of social communicative cues in patients with major depression // Human Brain Mapping. 2020. V. 41. № 13. P. 3541–3554. https://doi.org/10.1002/hbm.25027
  118. Surguladze S., Brammer M.J., Keedwell P. et al. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder // Biological Psychiatry. 2005. V. 57. № 3. P. 201–209. https://doi.org/10.1016/j.biopsych.2004.10.028
  119. Szczepanik J.E., Brycz H., Kleka P. et al. Metacognition and emotion – How accurate perception of own biases relates to positive feelings and hedonic capacity // Conscious & Cognition. 2020. V. 82. e102936. https://doi.org/10.1016/j.concog.2020.102936
  120. Takamura M., Okamoto Y., Okada G. et al. Patients with major depressive disorder exhibit reduced reward size coding in the striatum // Progress in Neuropsychopharmacology & Biological Psychiatry. 2017. V. 79. (Pt. B). P. 317–323. https://doi.org/10.1016/j.pnpbp.2017.07.006
  121. Taylor N., Hollis J.P., Corcoran S. et al. Impaired reward responsiveness in schizophrenia // Schizophrenia Research. 2018. V. 199. P. 46–52. https://doi.org/10.1016/j.schres.2018.02.057
  122. Tepfer L.J., Alloy L.B., Smith D.V. Family history of depression is associated with alterations in task-dependent connectivity between the cerebellum and ventromedial prefrontal cortex // Depression & Anxiety. 2021. V. 38. № 5. P. 508–520. https://doi.org/10.1002/da.23143
  123. Thai M., Başgöze Z., Klimes–Dougan B. et al. Neural and Behavioral Correlates of Clinical Improvement to Ketamine in Adolescents With Treatment Resistant Depression // Frontiers in Psychiatry. 2020. V. 11. e820. https://doi.org/10.3389/fpsyt.2020.00820
  124. Uldall S.W., Madsen K.H., Siebner H.R. et al. Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder – A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees // Chronic Stress. 2020. V. 4. e2470547020917623. https://doi.org/10.1177/2470547020917623
  125. Wacker J., Dillon D.G., Pizzagalli D.A. The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: integration of resting EEG, fMRI, and volumetric techniques // Neuroimage. 2009. V. 46. № 1. P. 327–337. https://doi.org/10.1016/j.neuroimage.2009.01.058
  126. Wade B.S.C., Hellemann G., Espinoza R.T. et al. Accounting for symptom heterogeneity can improve neuroimaging models of antidepressant response after electroconvulsive therapy // Human Brain Mapping. 2021. V. 42. № 16. P. 5322–5333. https://doi.org/10.1002/hbm.25620
  127. Wade B.S.C., Hellemann G., Espinoza R.T. et al. Depressive Symptom Dimensions in Treatment-Resistant Major Depression and Their Modulation With Electroconvulsive Therapy // J. ECT. 2020. V. 36(2). P. 123–129. https://doi.org/10.1097/YCT.0000000000000623
  128. Walsh E.C., Eisenlohr-Moul T.A., Minkel J. et al. Pretreatment brain connectivity during positive emotion upregulation predicts decreased anhedonia following behavioral activation therapy for depression // J. Affective Disorders. 2019. V. 243. P. 188–192. https://doi.org/10.1016/j.jad.2018.09.065
  129. Wang Y., Deng Y., Fung G. et al. Distinct structural neural patterns of trait physical and social anhedonia: evidence from cortical thickness, subcortical volumes and inter-regional correlations // Psychiatry Research. 2014. V. 224. № 3. P. 184–191. https://doi.org/10.1016/j.pscychresns.2014.09.005
  130. Wang Y., Li Z., Liu W.-H. et al. Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing // Schizophrenia Bulletin. 2018. V. 44. (S. 2). P. S491–S500. https://doi.org/10.1093/schbul/sby036
  131. Wang Y., Liu W.-H., Li Z. et al. Altered corticostriatal functional connectivity in individuals with high social anhedonia // Psychological Medicine. 2016. V. 46. № 1. P. 125–135. https://doi.org/10.1017/S0033291715001592
  132. Wang Y., Liu W.-H., Li Z. et al. Dimensional schizotypy and social cognition: an fMRI imaging study // Frontiers in Behavioral Neuroscience. 2015. V. 9. e133. https://doi.org/10.3389/fnbeh.2015.00133
  133. Wang Y., Tang S., Zhang L. et al. Data-driven clustering differentiates subtypes of major depressive disorder with distinct brain connectivity and symptom features // British J. Psychiatry. 2021. V. 219. № 5. P. 606–613. https://doi.org/10.1192/bjp.2021.103
  134. Wang Y.-Z., Han Y., Zhao J.-J. et al. Brain activity in patients with deficiency versus excess patterns of major depression: A task fMRI study // Complementary Therapies in Medicine. 2019. V. 42. P. 292–297. https://doi.org/10.1016/j.ctim.2018.12.006
  135. Ward J., Lyall L.M., Bethlehem R.A.I. et al. Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure // Translational Psychiatry. 2019. V. 9. № 1. e327. https://doi.org/10.1038/s41398-019-0635-y
  136. Waugh C.E., Hamilton J.P., Chen M.C. et al. Neural temporal dynamics of stress in comorbid major depressive disorder and social anxiety disorder // Biology of Mood & Anxiety Disorders. 2012. V. 2. e11. https://doi.org/10.1186/2045-5380-2-11
  137. Whitton A.E., Kumar P., Treadway M.T. et al. Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework // Biological Psychiatry: Cognitive Neuroscience & Neuroimaging. 2021. V. 6. № 7. P. 706–715. https://doi.org/10.1016/j.bpsc.2021.01.004
  138. Yang X., Huang J., Roser M.E., Xie G. Anhedonia reduction correlates with increased ventral caudate connectivity with superior frontal gyrus in depression // Journal of Psychiatric Research. 2022. V. 151. P. 286–290. https://doi.org/10.1016/j.jpsychires.2022.04.030
  139. Yang X.-H., Wang Y., Wang D.F. et al. White matter microstructural abnormalities and their association with anticipatory anhedonia in depression // Psychiatry Research: Neuroimaging. 2017. V. 264. P. 29–34. https://doi.org/10.1016/j.pscychresns.2017.04.005
  140. Yang Z.-Y., Zhang R.-T., Li Y. et al. Functional connectivity of the default mode network is associated with prospection in schizophrenia patients and individuals with social anhedonia // Progress in Neuropsychopharmacology & Biological Psychiatry. 2019. V. 92. P. 412–420. https://doi.org/10.1016/j.pnpbp.2019.02.008
  141. Young K.S., Bookheimer S.Y., Nusslock R. et al. Dysregulation of threat neurociruitry during fear extinction: the role of anhedonia // Neuropsychopharmacology. 2021. V. 46. № 9. P. 1650–1657. https://doi.org/10.1038/s41386-021-01003-8
  142. Yu M., Cullen N., Linn K.A. et al. Structural brain measures linked to clinical phenotypes in major depression replicate across clinical centres // Molecular Psychiatry. 2021. V. 26. № 7. P. 2764–2775. https://doi.org/10.1038/s41380-021-01039-8
  143. Zhang B., Lin P., Shi H. et al. Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis // Brain Imaging & Behavior. 2016. V. 10. № 3. P. 920–939. https://doi.org/10.1007/s11682-015-9457-6
  144. Zhang H., Harris L., Split M. et al. Anhedonia and individual differences in orbitofrontal cortex sulcogyral morphology // Human Brain Mapping. 2016. V. 37. № 11. P. 3873–3881. https://doi.org/10.1002/hbm.23282
  145. Zhang R.-T., Yang Z.-Y., Wang Y.M. et al. Affective forecasting in individuals with social anhedonia: The role of social components in anticipated emotion, prospection and neural activation // Schizophrenia Research. 2020. V. 215. P. 322–329. https://doi.org/10.1016/j.schres.2019.10.006
  146. Zhang T., He K., Bai T. et al. Altered neural activity in the reward-related circuit and executive control network associated with amelioration of anhedonia in major depressive disorder by electroconvulsive therapy // Progress in Neuropsychopharmacology & Biological Psychiatry. 2021. V. 109. e110193. https://doi.org/10.1016/j.pnpbp.2020.110193
  147. Zhang Y.-J., Cai X.-L., Hu H.-X. et al. Social brain network predicts real-world social network in individuals with social anhedonia // Psychiatry Research: Neuroimaging. 2021. V. 317. e111390. https://doi.org/10.1016/j.pscychresns.2021.111390
  148. Zhang Y.-J., Pu C.-C., Wang Y.-M. et al. Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia // Schizophrenia Research. 2021. V. 232. P. 77–84. https://doi.org/10.1016/j.schres.2021.05.016
  149. Zhu X., Ward J., Cullen B. et al. Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank // Translational Psychiatry. 2021. V. 11. № 1. e395. https://doi.org/10.1038/s41398-021-01522-4

Supplementary files

Supplementary Files
Action
1. JATS XML
2.

Download (482KB)
3.

Download (345KB)
4.

Download (301KB)
5.

Download (2MB)

Copyright (c) 2023 М.Е. Мельников

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies