Zebrafish as a Promising Model in Translational Neurobiology and Biomedicine

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Abstract

—High prevalence of the central nervous system disorders necessitates novel methods and approaches for their pharmacological correction. Traditionally used rodent models are limited by high costs of research, complex maintenance and care, and long development. The use of alternative, aquatic model organisms, such as the zebrafish (Danio rerio), in translational neuroscience and medicine allows for fast efficient experimentation with easy maintenance, manipulations, and rapid development. Zebrafish are also sensitive to major classes of physiologically active agents, which makes this model indispensable for preclinical studies of a wide range of small molecules. The similarity of neurochemical systems, the presence of major neurotransmitters, a high degree of genetic and physiological homology with humans, the availability of both larval and adult fish models, and embryonic transparency provide multiple possibilities for using this organism to model CNS pathologies and its genetic and environmental causes.

Авторлар туралы

T. Kolesnikova

Neurobiology Department, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology; Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg

Хат алмасуға жауапты Автор.
Email: philimontani@yandex.ru
Russia, 354340, Sochi; Russia, 197758 , Pesochny

N. Ilyin

Almazov Medical Research Centre, Institute of Experimental Medicine, Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University; Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg

Email: philimontani@yandex.ru
Russia, 197341, St. Petersburg; Russia, 199034, St. Petersburg; Russia, 197758 , Pesochny

M. Kotova

Neurobiology Department, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology

Email: philimontani@yandex.ru
Russia, 354340, Sochi

A. Kaluev

Neurobiology Department, Scientific Center of Genetics and Life Sciences, Sirius University of Science and Technology; Almazov Medical Research Centre, Institute of Experimental Medicine, Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University; Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg

Email: philimontani@yandex.ru
Russia, 354340, Sochi; Russia, 197341, St. Petersburg; Russia, 199034, St. Petersburg; Russia, 197758 , Pesochny

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