Changes in the visual areas of the cerebral cortex in children with left-sided anisometropic amblyopia according to structural MRI and resting-state fMRI
- Authors: Gorev V.V.1, Gorbunov A.V.1, Panikratova Y.R.2, Tomyshev A.S.2, Hatsenko I.E.1, Kuleshov N.N.1, Salmasi J.M.3, Hasanova K.A.1, Balashova L.M.4, Lobanova E.I.3, Lebedeva I.S.2
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Affiliations:
- Morozov Children Clinical Hospital
- Mental Health Research Center
- Pirogov Russian National Research Medical University
- Noncommercial partnership «International scientific and practical center for tissue proliferation»
- Issue: Vol 38, No 1 (2024)
- Pages: 30-44
- Section: ЗРИТЕЛЬНАЯ СИСТЕМА
- URL: https://journals.rcsi.science/0235-0092/article/view/255484
- DOI: https://doi.org/10.31857/S0235009224010027
- ID: 255484
Cite item
Abstract
Thanks to the development of structural and functional magnetic resonance imaging (MRI) methods, in recent decades there has been a lot of research aimed at elucidating brain abnormalities caused by amblyopia. In the cases of this prevalent visual disorder, the anomalies causing decreased visual acuity and other visual disabilities cannot be determined by standard ophthalmologic examination. Since there are several types of this disorder that are fundamentally different in etiology, it is natural to suggest the presence of different types of corresponding brain abnormalities. In this regard, before obtaining a general picture of the pathogenesis of amblyopia, studies conducted on groups of specially selected similar patients are very important. This paper presents the results of a study of school-age children with left-sided anisometropic amblyopia. In the patients investigated, MRI data revealed interhemispheric differences in the thickness of the lateral occipital cortex, and resting-state fMRI revealed interhemispheric differences in the local coherence of the hemodynamic signal within 17 Brodmann area and in the functional connectivity between 17 and 18+19 Brodmann areas. The data obtained contribute to the creation of a general MRI database on the pathophysiology of amblyopia, help clarify some controversial issues and indicate the advisability of using resting-state fMRI in ophthalmology.
Full Text
About the authors
V. V. Gorev
Morozov Children Clinical Hospital
Email: 14-06-60@mail.ru
Russian Federation, 119049, Moscow, 4-i Dobryninsky lane, 1/9
A. V. Gorbunov
Morozov Children Clinical Hospital
Email: 14-06-60@mail.ru
Russian Federation, 1, 119049, Moscow, 4-i Dobryninsky lane, 1/9
Ya. R. Panikratova
Mental Health Research Center
Email: 14-06-60@mail.ru
Russian Federation, 115522, Moscow, Kashirskoe highway, 34
A. S. Tomyshev
Mental Health Research Center
Email: 14-06-60@mail.ru
Russian Federation, 115522, Moscow, Kashirskoe highway, 34
I. E. Hatsenko
Morozov Children Clinical Hospital
Author for correspondence.
Email: 14-06-60@mail.ru
Russian Federation, 119049, Moscow, 4-i Dobryninsky lane, 1/9
N. N. Kuleshov
Morozov Children Clinical Hospital
Email: 14-06-60@mail.ru
Russian Federation, 119049, Moscow, 4-i Dobryninsky lane, 1/9
J. M. Salmasi
Pirogov Russian National Research Medical University
Email: 14-06-60@mail.ru
Russian Federation, 117997, Moscow, Ostrovityanova street, 1
K. A. Hasanova
Morozov Children Clinical Hospital
Email: 14-06-60@mail.ru
Russian Federation, 119049, Moscow, 4-i Dobryninsky lane, 1/9
L. M. Balashova
Noncommercial partnership «International scientific and practical center for tissue proliferation»
Email: 14-06-60@mail.ru
Russian Federation, 119034, Moscow, Prechistenka street, 29/14
E. I. Lobanova
Pirogov Russian National Research Medical University
Email: 14-06-60@mail.ru
Russian Federation, 117997, Moscow, Ostrovityanova street, 1
I. S. Lebedeva
Mental Health Research Center
Email: 14-06-60@mail.ru
Russian Federation, 115522, Moscow, Kashirskoe highway, 34
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