Copper(II) and Zinc(II) Complexes with Heterocyclic Acid Anions and 3,5-Dimethylpyrazole: Synthesis, Structure, and Biological Properties

M. A. Uvarova; Уварова М. А.; M. V. Novikova; Новикова М. В.; V. A. Eliseenkova; Елисеенкова В. А.; D. E. Baravikov; Баравиков Д. Е.; F. M. Dolgushin; Долгушин Ф. М.; O. B. Bekker; Беккер О. Б.; E. V. Fatushina; Фатюшина Е. В.; M. A. Kiskin; Кискин М. А.; I. L. Eremenko; Еременко И. Л.; I. A. Lutsenko; Луценко И. А.

doi:10.31857/S0132344X23600200

Copper(II) and Zinc(II) Complexes with Heterocyclic Acid Anions and 3,5-Dimethylpyrazole: Synthesis, Structure, and Biological Properties

Authors: Uvarova M.A.¹, Novikova M.V.¹^,2, Eliseenkova V.A.³, Baravikov D.E.¹^,4, Dolgushin F.M.¹, Bekker O.B.⁵, Fatushina E.V.¹, Kiskin M.A.¹, Eremenko I.L.¹, Lutsenko I.A.¹
Affiliations:
1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
2. Moscow Institute of Physics and Technology, Moscow, Russia
3. School no. 1553 named after Vernadsky, Moscow, Russia
4. Mendeleev University of Chemical Technology of Russia, Moscow, Russia
5. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
Issue: Vol 49, No 10 (2023)
Pages: 651-658
Section: Articles
URL: https://journals.rcsi.science/0132-344X/article/view/162304
DOI: https://doi.org/10.31857/S0132344X23600200
EDN: https://elibrary.ru/OCUHPJ
ID: 162304

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Abstract

The reaction of copper(II) and zinc(II) acetates with 3-furancarboxylic (HFur) and 2-thiophenecarboxylic (HTph) acids with subsequent addition of 3,5-dimethylpyrazole (HDmpz) gave mononuclear complexes [M(L)2(HDmpz)2] (M = Cu(II), L = Fur– (I), Tph– (II); Zn(II), L = Fur– (III)). The structures of compounds I–III were determined by X-ray diffraction. According to X-ray diffraction data, I and II are isostructural: the central Cu(II) atom occurs in a square planar environment formed by two oxygen atoms of carboxylate anions and HDmpz nitrogen atoms; in III, the Zn atom is in the tetrahedral environment of two furoate anions and HDmpz molecules, thus forming the {MO2N2} groups. The complexes are additionally stabilized in the crystal by inter- (I and II) and intramolecular (III) hydrogen bonds. The biological activity of I–III was determined in relation to the non-pathogenic Mycolicibacterium smegmatis.

Keywords

copper(II) and zinc(II) complexes, 3, 5-dimethylpyrazole, 3-furancarboxylic acid, 2-thiophenecarboxylic acid, crystal structure, biological activity

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