Synthesis, Study of Antitumor Activity, and Effect of (4-Alkoxyphenyl)(3-aryloxy-2-yl)methanones on Tumor DNA In Vitro

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Abstract

Condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution yielded (2E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones. Subsequent oxidation of the latter with hydrogen peroxide in a water-ethanol system in a basic medium at room temperature yielded the corresponding epoxy derivatives. The effect of the synthesized compounds on tumor DNA methylation processes in vitro and the antitumor activity of [4-(pentyloxy)phenyl)](3-phenyloxiran-2-yl)methanone in vivo were assessed.

About the authors

A. U. Isakhanyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: anush.isakhanyan.51@mail.ru
Yerevan, 0014 Armenia

N. Z. Hakobyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, 0014 Armenia

Z. A. Hovasyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, 0014 Armenia

S. V. Dilanyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, 0014 Armenia

L. E. Nersesyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, 0014 Armenia

A. S. Aharonyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, 0014 Armenia

I. S. Danielyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, 0014 Armenia

H. A. Panosyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, 0014 Armenia

A. A. Harutyunyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, 0014 Armenia

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