The Role of Phospholipid Derivatives of Cyclodextrins in the Formation of Stable Lipid Nanoparticles for Drug Delivery

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Abstract

This review article deals with physical methods for investigating the structural characteristics of inclusion complexes of supramers of phospholipid derivatives of cyclodextrins. Phospholipid derivatives of cyclodextrins are formed by attaching a phospholipid moiety to the cyclodextrin molecule. This modification imparts additional structural features to the cyclodextrin, increasing its solubility and stability in aqueous media. These new compounds can self-assemble in aqueous media into different types of supramolecular nanocomplexes. Biomedical applications are envisaged for nanoencapsulation of drug molecules in hydrophobic interchain volumes and nanocavities of amphiphilic cyclodextrins (serving as drug carriers or pharmaceutical excipients), antitumour phototherapy, gene delivery, and protection of unstable active ingredients by complexation of inclusions in nanostructured media. The focus is on the study of nanoparticle morphology, as efficient delivery systems must fulfil certain requirements. Classical physical methods cannot provide detailed information on the properties of potential structures for biomedical applications. For this purpose, the search for new non-invasive approaches is necessary.

About the authors

E. D. Belitskaya

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)

Email: belitskayakatya@yandex.ru
Moscow, 117997 Russia; Dolgoprudny, 141701 Russia

V. A. Oleinokov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; National Research Nuclear University “MEPhI”

Moscow, 117997 Russia; Moscow, 115409 Russia

A. V. Zalygin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Lebedev Physical Institute of the Russian Academy of Sciences, Troitsk Branch

Moscow, 117997 Russia; Moscow, Troitsk, 108840 Russia

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