Synthesis and Evaluation of the Antiviral Activity of 5-Halogen-2'-Azido-Substituted Derivatives of Cytidine and N-Hydroxycytidine on a Panel of RNA Viruses, Including SARS-CoV-2
- Autores: Kamzeeva P.1, Kozlovskaya L.2,3, Belyaev E.4, Chistov A.1, Alferova V.1, Yakovchuk E.2,3, Borodulina M.2,3, Karpova E.2, Kolpakova E.2, Aralov A.3
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Afiliações:
- Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Chumakov Scientific Center for Research and Development of Immune-and-Biological Products, Russian Academy of Sciences (Institute of Poliomyelitis), village of the Institute of Poliomyelitis
- Sechenov First Moscow State Medical University
- Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Science
- Edição: Volume 49, Nº 6 (2023)
- Páginas: 657-664
- Seção: ПИСЬМА РЕДАКТОРУ
- URL: https://journals.rcsi.science/0132-3423/article/view/148165
- DOI: https://doi.org/10.31857/S0132342323060064
- EDN: https://elibrary.ru/PMYJGZ
- ID: 148165
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Resumo
Coronavirus disease 2019 (COVID-19) is a new global pandemic with high morbidity and mortality caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). N-Hydroxycytidine derivatives show promise for combating viral diseases, and in particular, molnupiravir has recently been approved for emergency prophylaxis in the early stages after infection with SARS-CoV-2. Here, a scheme for the synthesis of 5‑halo-2'-azido-substituted derivatives of cytidine and N-hydroxycytidine is proposed. The synthesized compounds were tested on a panel of six RNA viruses, including SARS-CoV-2, enteroviruses, CHIKV, and HIV-1. A number of compounds were able to inhibit the reproduction of SARS-CoV-2 and CHIKV viruses in the micromolar range without noticeable cytotoxicity. The structures of the leader compounds can be used as a starting point for further design of antiviral agents.
Palavras-chave
Sobre autores
P. Kamzeeva
Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Baruh238@mail.ru
Russia, 117997, Moscow, ul. Miklukho-Maklaya 16/10
L. Kozlovskaya
Chumakov Scientific Center for Research and Development of Immune-and-Biological Products, Russian Academyof Sciences (Institute of Poliomyelitis), village of the Institute of Poliomyelitis; Sechenov First Moscow State Medical University
Email: Baruh238@mail.ru
Russia, 108819, Moscow, settlement Moskovskiy, 8/1; Russia, 119991, Moscow, ul. Trubetskaya 8/2
E. Belyaev
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Science
Email: Baruh238@mail.ru
Russia, 119071, Moscow, Leninskiy prosp. 31
A. Chistov
Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Baruh238@mail.ru
Russia, 117997, Moscow, ul. Miklukho-Maklaya 16/10
V. Alferova
Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Baruh238@mail.ru
Russia, 117997, Moscow, ul. Miklukho-Maklaya 16/10
E. Yakovchuk
Chumakov Scientific Center for Research and Development of Immune-and-Biological Products, Russian Academyof Sciences (Institute of Poliomyelitis), village of the Institute of Poliomyelitis; Sechenov First Moscow State Medical University
Email: Baruh238@mail.ru
Russia, 108819, Moscow, settlement Moskovskiy, 8/1; Russia, 119991, Moscow, ul. Trubetskaya 8/2
M. Borodulina
Chumakov Scientific Center for Research and Development of Immune-and-Biological Products, Russian Academyof Sciences (Institute of Poliomyelitis), village of the Institute of Poliomyelitis; Sechenov First Moscow State Medical University
Email: Baruh238@mail.ru
Russia, 108819, Moscow, settlement Moskovskiy, 8/1; Russia, 119991, Moscow, ul. Trubetskaya 8/2
E. Karpova
Chumakov Scientific Center for Research and Development of Immune-and-Biological Products, Russian Academyof Sciences (Institute of Poliomyelitis), village of the Institute of Poliomyelitis
Email: Baruh238@mail.ru
Russia, 108819, Moscow, settlement Moskovskiy, 8/1
E. Kolpakova
Chumakov Scientific Center for Research and Development of Immune-and-Biological Products, Russian Academyof Sciences (Institute of Poliomyelitis), village of the Institute of Poliomyelitis
Email: Baruh238@mail.ru
Russia, 108819, Moscow, settlement Moskovskiy, 8/1
A. Aralov
Sechenov First Moscow State Medical University
Autor responsável pela correspondência
Email: Baruh238@mail.ru
Russia, 119991, Moscow, ul. Trubetskaya 8/2
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