Variation in particular biochemical indicators, cytokine and adipokine profiles of the blood, and the structural and functional parameters of the liver in patients with nonalcoholic fatty liver disease and different genotypes by the polymorphic locus A313G of the GSTP1 gene
- Autores: Prysyazhnyuk V.P.1, Rossokha Z.I.2, Gorovenko N.G.3
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Afiliações:
- Bukovinian State Medical University
- Reference Center for Molecular Diagnostics
- Shupyk National Medical Academy of Postgraduate Education
- Edição: Volume 51, Nº 6 (2017)
- Páginas: 455-461
- Seção: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/173768
- DOI: https://doi.org/10.3103/S0095452717060111
- ID: 173768
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Resumo
Variation in particular biochemical indicators, cytokine and adipokine profile parameters of the blood, and the structural and functional parameters of the liver have been studied in patients with nonalcoholic fatty liver disease (NAFLD) and different genotypes by the polymorphic locus A313G of GSTP gene (rs 1695). It has been established that the G allele of the GSTP gene (A313G) is significantly more frequently met in NAFLD patients than in healthy individuals. Higher activity of alanine aminotransferase and higher level of leptin, as well as lower adiponectin blood content, were recorded in the carriers of the G allele of the GSTP gene (A313G) as compared to patients with the given gene AA genotype. Higher interleukin-10 blood content was also observed in homozygous G allele carriers of NAFLD patients compared with the patients with the AA and AG genotypes. The patients with the G allele of the GSTP1 gene had a larger right lobe of liver than homozygous carriers of the given gene A allele.
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Sobre autores
V. Prysyazhnyuk
Bukovinian State Medical University
Email: zoiroh071@gmail.com
Ucrânia, Chernivtsi
Z. Rossokha
Reference Center for Molecular Diagnostics
Autor responsável pela correspondência
Email: zoiroh071@gmail.com
Ucrânia, Kyiv
N. Gorovenko
Shupyk National Medical Academy of Postgraduate Education
Email: zoiroh071@gmail.com
Ucrânia, Kyiv
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