Role of the genetic component in osteopenic syndrome pathogenesis in children from regions with a polluted environment
- 作者: Kech N.R.1, Hnatejko O.Z.1, Makukh H.V.1, Lukjanenko N.S.1, Lychkovska O.L.1
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隶属关系:
- Institute of Hereditary Pathology
- 期: 卷 52, 编号 1 (2018)
- 页面: 46-53
- 栏目: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/173815
- DOI: https://doi.org/10.3103/S009545271801005X
- ID: 173815
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详细
Molecular genetic data and the results of an instrumental examination (ultrasonic densitometry) in 125 children from regions with anthropogenic pollution of the environment and 31 control group children from an area with an unpolluted environment have been analyzed. The molecular-genetic approach was used to study TaqI and ApaI polymorphic loci of the vitamin D3 receptor gene. Osteopenia and osteoporosis diagnosis frequency was 1.5 times higher in children from regions with a polluted environment. A decrease of bone mineral density was most common in children with tt and Tt genotypes (100 and 45%, respectively) and those with AA and Aa genotypes (83 and 42%, respectively). This is in agreement with published data on lower values of this parameter being associated with the ttAA genotype. Comprehensive assessment of instrumental and clinical laboratory parameters of bone density in carriers of certain allelic variants of the TaqI (rs731236) and ApaI (rs739837) polymorphic loci of the vitamin D3 receptor gene has been performed.
作者简介
N. Kech
Institute of Hereditary Pathology
编辑信件的主要联系方式.
Email: NataliaKech@ukr.net
乌克兰, Lviv
O. Hnatejko
Institute of Hereditary Pathology
Email: NataliaKech@ukr.net
乌克兰, Lviv
H. Makukh
Institute of Hereditary Pathology
Email: NataliaKech@ukr.net
乌克兰, Lviv
N. Lukjanenko
Institute of Hereditary Pathology
Email: NataliaKech@ukr.net
乌克兰, Lviv
O. Lychkovska
Institute of Hereditary Pathology
Email: NataliaKech@ukr.net
乌克兰, Lviv
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