Analysis of molecular genetic study on the polymorphic C-159T locus of the CD14 gene in children with increased risk of recurrent episodes of acute obstructive bronchitis
- Authors: Kens O.V.1, Gnateyko O.Z.1, Lukyanenko N.S.1, Vishtak N.V.1, Bergtravm V.I.2
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Affiliations:
- Institute of Hereditary Pathology
- Okhmatdyt Regional Children’s Clinical Hospital
- Issue: Vol 51, No 5 (2017)
- Pages: 365-370
- Section: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/173716
- DOI: https://doi.org/10.3103/S0095452717050036
- ID: 173716
Cite item
Abstract
A molecular genetic study of the polymorphic C-159T locus of the CD14 gene has been carried out in 31 children with recurrent episodes of acute obstructive bronchitis as well as in a cohort of 50 randomly sampled subjects forming the control group. As a result of the study, no higher statistically significant frequency of the CC, CT, and TT genotypes has been recorded at the polymorphic C-159T locus of the CD14 gene among children of the main group compared with the control. However, there is a trend towards a more frequent observation of the TT genotype among children with recurrent episodes of acute obstructive bronchitis compared with the control group (32.25 vs. 22.0%).
About the authors
O. V. Kens
Institute of Hereditary Pathology
Author for correspondence.
Email: kensle@mail.ru
Ukraine, Lviv
O. Z. Gnateyko
Institute of Hereditary Pathology
Email: kensle@mail.ru
Ukraine, Lviv
N. S. Lukyanenko
Institute of Hereditary Pathology
Email: kensle@mail.ru
Ukraine, Lviv
N. V. Vishtak
Institute of Hereditary Pathology
Email: kensle@mail.ru
Ukraine, Lviv
V. I. Bergtravm
Okhmatdyt Regional Children’s Clinical Hospital
Email: kensle@mail.ru
Ukraine, Lviv