Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion
- Authors: Storozhenko K.V.1, Shkarupa V.M.2
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Affiliations:
- Bogomolets National Medical University
- National Pirogov Memorial Medical University
- Issue: Vol 51, No 5 (2017)
- Pages: 361-364
- Section: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/173711
- DOI: https://doi.org/10.3103/S0095452717050103
- ID: 173711
Cite item
Abstract
The molecular-genetic testing of the polymorphic rs2981579 (C>T) locus of the FGFR2 gene as the marker of increased predisposition to the development of mesial occlusion was carried out in 110 patients with mesial occlusion and 103 general-population control subjects from Ukraine. It was shown that polymorphism rs2981579 in gene FGFR2 is associated with mesial occlusion (OR = 1.67, 95% CI = 1.14–2.45, p = 0.009). Compared to CC carriers, TT+CT carriers had a 3.21-fold higher risk of mesial occlusion (95% CI = 1.57–6.57, p = 0.001). We found the protective effect of the homozygous allele C on mesial occlusion development (OR = 0.31, p = 0.001). This is the first published data on FGFR2 polymorphisms rs2981579 (C>T) in patients with mesial occlusion.
Keywords
About the authors
K. V. Storozhenko
Bogomolets National Medical University
Email: shkarupa_vlad@bigmir.net
Ukraine, Kyiv, 01601
V. M. Shkarupa
National Pirogov Memorial Medical University
Author for correspondence.
Email: shkarupa_vlad@bigmir.net
Ukraine, Vinnytsya, 21000
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