Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion


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Abstract

The molecular-genetic testing of the polymorphic rs2981579 (C>T) locus of the FGFR2 gene as the marker of increased predisposition to the development of mesial occlusion was carried out in 110 patients with mesial occlusion and 103 general-population control subjects from Ukraine. It was shown that polymorphism rs2981579 in gene FGFR2 is associated with mesial occlusion (OR = 1.67, 95% CI = 1.14–2.45, p = 0.009). Compared to CC carriers, TT+CT carriers had a 3.21-fold higher risk of mesial occlusion (95% CI = 1.57–6.57, p = 0.001). We found the protective effect of the homozygous allele C on mesial occlusion development (OR = 0.31, p = 0.001). This is the first published data on FGFR2 polymorphisms rs2981579 (C>T) in patients with mesial occlusion.

About the authors

K. V. Storozhenko

Bogomolets National Medical University

Email: shkarupa_vlad@bigmir.net
Ukraine, Kyiv, 01601

V. M. Shkarupa

National Pirogov Memorial Medical University

Author for correspondence.
Email: shkarupa_vlad@bigmir.net
Ukraine, Vinnytsya, 21000

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