Synthesis of 4-Phenylpyrrolidone Derivatives with Anticonvulsant and Nootropic Activity
- 作者: Zhmurenko L.1, Litvinova S.1, Mokrov G.1, Kovalev I.1, Voronina T.1, Nerobkova L.1, Gudasheva T.1
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隶属关系:
- V. V. Zakusov Research Institute of Pharmacology
- 期: 卷 53, 编号 5 (2019)
- 页面: 429-435
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245797
- DOI: https://doi.org/10.1007/s11094-019-02015-x
- ID: 245797
如何引用文章
详细
New 4-phenylpyrrolidone derivatives were designed from racetam structures that combine nootropic and anticonvulsant activity. The proposed compounds were synthesized using 4-phenylpyrrolidone and aromatic amines. The anticonvulsant activity of the new compounds was studied. The structure–activity relationship was analyzed. The most active compound was the 2,6-dimethylanilide of (2-oxo-4-phenylpyrrolidin-1-yl)acetic acid at doses of 2.5 – 5.0 mg/kg, which surpassed the reference drug levetiracetam at doses of 2.5 – 600 mg/kg in all tests and possessed distinct nootropic activity that was comparable to that of the reference nootropic drug piracetam at a dose of 400 mg/kg.
作者简介
L. Zhmurenko
V. V. Zakusov Research Institute of Pharmacology
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
S. Litvinova
V. V. Zakusov Research Institute of Pharmacology
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
G. Mokrov
V. V. Zakusov Research Institute of Pharmacology
编辑信件的主要联系方式.
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
I. Kovalev
V. V. Zakusov Research Institute of Pharmacology
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
T. Voronina
V. V. Zakusov Research Institute of Pharmacology
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
L. Nerobkova
V. V. Zakusov Research Institute of Pharmacology
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
T. Gudasheva
V. V. Zakusov Research Institute of Pharmacology
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315