Conjugates of Prostate-Specific Membrane Antigen Ligands with Antitumor Drugs
- 作者: Uspenskaya A.1, Machulkin A.1, Mazhuga A.1,2, Beloglazkina E.1
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隶属关系:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- D. Mendeleev University of Chemical Technology of Russia
- 期: 卷 53, 编号 4 (2019)
- 页面: 288-297
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245738
- DOI: https://doi.org/10.1007/s11094-019-01994-1
- ID: 245738
如何引用文章
详细
Conjugates for targeted delivery that are based on low-molecular-mass prostate specific membrane antigen (PSMA) inhibitors are widely used and developed because of the deficiencies of existing methods for treating and diagnosing prostate cancer. The major classes of low-molecular-mass PSMA inhibitors, drug classes, and their mechanisms of action are discussed. Therapeutic conjugates for targeted delivery that are based on them are analyzed. Structural features of the linker that affect the biological activity and selectivity are identified.
作者简介
A. Uspenskaya
Department of Chemistry, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: uspenskaya.n@gmail.com
俄罗斯联邦, GSP-1, Moscow, 199991
A. Machulkin
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: uspenskaya.n@gmail.com
俄罗斯联邦, GSP-1, Moscow, 199991
A. Mazhuga
Department of Chemistry, M. V. Lomonosov Moscow State University; D. Mendeleev University of Chemical Technology of Russia
Email: uspenskaya.n@gmail.com
俄罗斯联邦, GSP-1, Moscow, 199991; Moscow, 125047
E. Beloglazkina
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: uspenskaya.n@gmail.com
俄罗斯联邦, GSP-1, Moscow, 199991