Synthesis and Anticonvulsant Activity of 4-Amino-3-Nitro-1-Thiocoumarins and 4-Amino-3-Nitroquinolin-2-Ones
- 作者: Mokrov G.1, Voronina T.1, Litvinova S.1, Kovalev I.1, Nerobkova L.1, Durnev A.1, Gudasheva T.1, Seredenin S.1
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隶属关系:
- V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- 期: 卷 53, 编号 3 (2019)
- 页面: 194-200
- 栏目: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/245680
- DOI: https://doi.org/10.1007/s11094-019-01978-1
- ID: 245680
如何引用文章
详细
Novel thiocoumarins and quinolin-2-ones were synthesized and screened for anticonvulsant activity. The structure–activity relationship of a series of synthesized compounds and previously prepared coumarin derivatives was analyzed. The methyl ester of N-(3-nitro-2-oxo-1,2-dihydroquinolin-4-yl)-4-aminobutyric acid (3a) at a dose of 12.5 mg/kg (i.p.) had the greatest anticonvulsant activity in mouse tests.
作者简介
G. Mokrov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
编辑信件的主要联系方式.
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
T. Voronina
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
S. Litvinova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
I. Kovalev
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
L. Nerobkova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
A. Durnev
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
T. Gudasheva
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
S. Seredenin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315