3D-Modeling of the Influence of Isomalt, Glucose, and Compaction Pressure on the Quality of Ascorbic-Acid Tablets
- 作者: Filimonova A.1, Tret’yakova Y.1, Gavrilov A.1
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隶属关系:
- Ural State Medical University
- 期: 卷 52, 编号 5 (2018)
- 页面: 467-472
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245251
- DOI: https://doi.org/10.1007/s11094-018-1841-2
- ID: 245251
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详细
The influence of the isomalt mass fraction in a mixture with glucose on the flowability, density, and elastic-plastic properties of the tableting mass and the quality of the obtained 1-g tablets (14 mm diameter) was studied. The flowability of the mixture decreased by 0.6 ± 0.06 g/c if the isomalt ST-PF content was increased by 10%. The curve for the bulk density had a distinct maximum near an isomalt–glucose ratio of 50:50. The tablet strength increased linearly by 55 ± 7 and 51 ± 7 N; the density, by 0.0036 ± 0.0002 and 0.076 ± 0.003 g/cm3; and the disintegration time, by 1.2 ± 0.2 and 1.7 ± 02 min if the isomalt ST-PF concentration in the mixture was increased to 35% and the compaction pressure to 350 N/cm2, respectively.
作者简介
A. Filimonova
Ural State Medical University
Email: chem@folium.ru
俄罗斯联邦, 3 – 108 Repina, Ekaterinburg, 620028
Yu. Tret’yakova
Ural State Medical University
Email: chem@folium.ru
俄罗斯联邦, 3 – 108 Repina, Ekaterinburg, 620028
A. Gavrilov
Ural State Medical University
Email: chem@folium.ru
俄罗斯联邦, 3 – 108 Repina, Ekaterinburg, 620028