Angio-Suppressive Effect of Sterols from Ardisia Pyramidalis (Cav.) Pers.
- 作者: Raga D.1, Herrera A.2, Alimboyoguen A.3, Shen C.4, Ragasa C.3
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隶属关系:
- Department of Biology, Ateneo De Manila University
- Institute of Biology, University of the Philippines, Diliman
- Chemistry Department, De La Salle University Science & Technology Complex
- National Research Institute of Chinese Medicine
- 期: 卷 51, 编号 8 (2017)
- 页面: 683-689
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244755
- DOI: https://doi.org/10.1007/s11094-017-1674-4
- ID: 244755
如何引用文章
详细
Spinasterol (1) and spinasteryl acetate (2) from the leaves of Ardisia pyramidalis (Cav.) Pers. (Myrsinaceae) were tested on duck chorioallantoic membrane (CAM) vascularity assay. The petechial to severe hemorrhaging, hyperemia, and the formation of ghost vessels were observed in CAMs treated with compounds 1 and 2. Both sterols have effectively suppressed blood vessel branching and inter-capillary elongation. High degree of vonWillebrand factor expression was observed in these CAMs treated with 1 and 2. This is further confirmed by the absence of the epithelial membrane antigen in all samples tested, suggesting that the main mechanism of angio-suppression is related to the action of von Willebrand factor which modulates other angiogenic factors. Spinasterol was found to be most effective in reducing the branch point formation and inter capillary distance with very minimal incidence of mortality, thus suggesting its potential as a source of phytopharmaceuticals.
作者简介
Dennis Raga
Department of Biology, Ateneo De Manila University
Email: consolacion.ragasa@dlsu.edu.ph
菲律宾, Loyola Heights, Quezon City
Annabelle Herrera
Institute of Biology, University of the Philippines, Diliman
Email: consolacion.ragasa@dlsu.edu.ph
菲律宾, Quezon City
Agnes Alimboyoguen
Chemistry Department, De La Salle University Science & Technology Complex
Email: consolacion.ragasa@dlsu.edu.ph
菲律宾, Leandro V. Locsin Campus, Biñan City, Laguna
Chien-Chang Shen
National Research Institute of Chinese Medicine
Email: consolacion.ragasa@dlsu.edu.ph
台湾, Li-Nong St. Ministry of Health and Welfare, Sec. 2, Taipei, 112
Consolacion Ragasa
Chemistry Department, De La Salle University Science & Technology Complex
编辑信件的主要联系方式.
Email: consolacion.ragasa@dlsu.edu.ph
菲律宾, Leandro V. Locsin Campus, Biñan City, Laguna