Acute Toxicity of Substituted Hydroquinones Evaluated by a Modified Probit Analysis Method
- 作者: Kalinichenko E.1, Nagibina K.1,2, Psareva N.2, Kanibolotskaya L.1
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隶属关系:
- Donetsk National University
- Stirolbiopharm Co.
- 期: 卷 51, 编号 6 (2017)
- 页面: 448-452
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244648
- DOI: https://doi.org/10.1007/s11094-017-1631-2
- ID: 244648
如何引用文章
详细
The LD50 values of methyl-, bromo-, and chlorohydroquinones were evaluated. Probit analysis calculations by the Bliss—Prozorovsky least-squares method were optimized using preliminary results of the OECD TG 425 Up-and-Down Procedure. The proposed modification allowed economic expenditures to be diminished by reducing the numbers of injected doses and experimental animals and could be applied to testing of substances by other drug administration modes. Correlation functions between the toxicity values and dissociation constants were obtained and allowed the LD50 values of the hydroquinone derivatives to be evaluated.
作者简介
E. Kalinichenko
Donetsk National University
Email: e.a.kalinichenko@gmail.com
乌克兰, 21 600-Letiya St., Vinnytsia, 21021
K. Nagibina
Donetsk National University; Stirolbiopharm Co.
Email: e.a.kalinichenko@gmail.com
乌克兰, 21 600-Letiya St., Vinnytsia, 21021; 97 Gorlovskoi Divizii St., Gorlovka, 84610
N. Psareva
Stirolbiopharm Co.
Email: e.a.kalinichenko@gmail.com
乌克兰, 97 Gorlovskoi Divizii St., Gorlovka, 84610
L. Kanibolotskaya
Donetsk National University
编辑信件的主要联系方式.
Email: e.a.kalinichenko@gmail.com
乌克兰, 21 600-Letiya St., Vinnytsia, 21021