Synthesis and Antimicrobial Activity of Tricyclic Quinazolinethiones
- 作者: Nasrullaev A.1, Islamova Z.1, Élmuradov B.1, Bektemirov A.2, Osipova S.1, Khushbaktova Z.1, Syrov V.1, Shakhidoyatov K.1
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隶属关系:
- S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Ministry of Public Health of the Republic of Uzbekistan
- 期: 卷 51, 编号 5 (2017)
- 页面: 355-360
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244607
- DOI: https://doi.org/10.1007/s11094-017-1614-3
- ID: 244607
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详细
Deoxyvasicine thione (III) and mackinazoline thione (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-thione, IV) were synthesized and condensed with aromatic and heterocyclic aldehydes at the α-methylene [CH2-3 (III) or CH2-6 (IV)]. Either 3- and 6-arylidene derivatives (V – XIII) or 6-hydroxymethylaryl derivatives (XIV) were formed depending on the reaction conditions. Formylation of IV synthesized the 6-hydroxymethylidene derivative (XV). 6-Chloro-, -hydroseleno-, and -anilinomethylidenemackinazoline thiones (XVI – XIX) were also synthesized. The antimicrobial activity of the synthesized compounds against S. aureus, E. coli, Bacillus cereus, Candida albicans, and Pseudomonas aeruginosa was studied.
作者简介
A. Nasrullaev
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
乌兹别克斯坦, Tashkent
Zh. Islamova
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
乌兹别克斯坦, Tashkent
B. Élmuradov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
乌兹别克斯坦, Tashkent
A. Bektemirov
Research Institute of Epidemiology, Microbiology and Infectious Diseases, Ministry of Public Health of the Republic of Uzbekistan
Email: zainab@icps.org.uz
乌兹别克斯坦, Tashkent
S. Osipova
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
乌兹别克斯坦, Tashkent
Z. Khushbaktova
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
编辑信件的主要联系方式.
Email: zainab@icps.org.uz
乌兹别克斯坦, Tashkent
V. Syrov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
乌兹别克斯坦, Tashkent
Kh. Shakhidoyatov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
乌兹别克斯坦, Tashkent