Synthesis and Antimicrobial Activity of Tricyclic Quinazolinethiones
- Autores: Nasrullaev A.1, Islamova Z.1, Élmuradov B.1, Bektemirov A.2, Osipova S.1, Khushbaktova Z.1, Syrov V.1, Shakhidoyatov K.1
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Afiliações:
- S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Ministry of Public Health of the Republic of Uzbekistan
- Edição: Volume 51, Nº 5 (2017)
- Páginas: 355-360
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244607
- DOI: https://doi.org/10.1007/s11094-017-1614-3
- ID: 244607
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Resumo
Deoxyvasicine thione (III) and mackinazoline thione (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-thione, IV) were synthesized and condensed with aromatic and heterocyclic aldehydes at the α-methylene [CH2-3 (III) or CH2-6 (IV)]. Either 3- and 6-arylidene derivatives (V – XIII) or 6-hydroxymethylaryl derivatives (XIV) were formed depending on the reaction conditions. Formylation of IV synthesized the 6-hydroxymethylidene derivative (XV). 6-Chloro-, -hydroseleno-, and -anilinomethylidenemackinazoline thiones (XVI – XIX) were also synthesized. The antimicrobial activity of the synthesized compounds against S. aureus, E. coli, Bacillus cereus, Candida albicans, and Pseudomonas aeruginosa was studied.
Sobre autores
A. Nasrullaev
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbequistão, Tashkent
Zh. Islamova
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbequistão, Tashkent
B. Élmuradov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbequistão, Tashkent
A. Bektemirov
Research Institute of Epidemiology, Microbiology and Infectious Diseases, Ministry of Public Health of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbequistão, Tashkent
S. Osipova
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbequistão, Tashkent
Z. Khushbaktova
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Autor responsável pela correspondência
Email: zainab@icps.org.uz
Uzbequistão, Tashkent
V. Syrov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbequistão, Tashkent
Kh. Shakhidoyatov
S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan
Email: zainab@icps.org.uz
Uzbequistão, Tashkent