Synthesis and Pharmacological Activity of Ethyl-2-Amino-1-Benzamido-4-Oxo-5-(2-Oxo-2-Arylethylidene)Pyrrolidine-3-Carboxylates
- 作者: Zykova S.1, Darovskikh A.1, Odegova T.2, Kiselev M.2, Igidov N.2
-
隶属关系:
- Perm Federal Penal Service Institute
- Perm State Pharmaceutical Academy
- 期: 卷 49, 编号 10 (2016)
- 页面: 657-660
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244268
- DOI: https://doi.org/10.1007/s11094-016-1347-8
- ID: 244268
如何引用文章
详细
Ethyl-2-amino-1-benzamido-4-oxo-5-(2-oxo-2-arylethylidene)pyrrolidine-3-carboxylates (IIa-g) were synthesized via recyclization of 3-(2-benzoylhydrazono)-5-arylfuran-2(3H)-ones (I) through the action of ethylcyanoacetate. The synthesized compounds were screened for biological activity and were found to have low toxicity. Ethyl-2-amino-1-benzamido-5-[2-(3, 4-dimethoxyphenyl)-2-oxoethylidene]-4-oxopyrrolidine-3-carboxylate exhibited antiradical activity in a diphenylpicrylhydrazyl (DPPH)-binding assay that was greater than that of the reference drug trolox. This same compound showed anti-inflammatory activity in a carrageenan edema model that was greater than that of diclofenac sodium. Assessment of antihypoxic activity in an acute normobaric hypoxia test found that ethyl-2-amino-1-benzamido-5-[2-oxo-2-(4-methylphenyl) ethylidene]-4-oxopyrrolidine-3-carboxylate was comparable with the succinic acid standard.
作者简介
S. Zykova
Perm Federal Penal Service Institute
编辑信件的主要联系方式.
Email: zykova.sv@rambler.ru
俄罗斯联邦, Ul. Karpinskogo, 125, Perm, 614012
A. Darovskikh
Perm Federal Penal Service Institute
Email: zykova.sv@rambler.ru
俄罗斯联邦, Ul. Karpinskogo, 125, Perm, 614012
T. Odegova
Perm State Pharmaceutical Academy
Email: zykova.sv@rambler.ru
俄罗斯联邦, Ul. Polevaya, 2, Perm, 614099
M. Kiselev
Perm State Pharmaceutical Academy
Email: zykova.sv@rambler.ru
俄罗斯联邦, Ul. Polevaya, 2, Perm, 614099
N. Igidov
Perm State Pharmaceutical Academy
Email: zykova.sv@rambler.ru
俄罗斯联邦, Ul. Polevaya, 2, Perm, 614099