Отправить статью по E-mail Synthesis and Cardiotropic Activity of 1-(Methoxybenzyl)-4-{2-[(Methoxybenzyl)-Amino]Ethyl}Piperazines
- Авторы: Mokrov G.V.1, Likhosherstov A.M.1, Barchukov V.V.1, Stolyaruk V.N.1, Tsorin I.B.1, Vititnova M.B.1, Rebeko A.G.1, Kryzhanovskii S.A.1, Gudasheva T.A.1
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Учреждения:
- V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- Выпуск: Том 53, № 9 (2019)
- Страницы: 786-791
- Раздел: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/246009
- DOI: https://doi.org/10.1007/s11094-019-02080-2
- ID: 246009
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Аннотация
A group of new 1-(methoxybenzyl)-4-{2-[(methoxybenzyl)amino]ethyl}piperazines (1) were synthesized. The relationship of the structure of the triazaalkane linker and the cardiotropic activity in a series of these compounds was compared with that of previously studied linear and cyclic methoxyphenyltriazaalkanes. The most active compound in the group was 1e (1-(3,4,5-trimethoxybenzyl)-4-{2-[(3,4,5-trimethoxybenzyl)amino] ethyl}piperazine trihydrochloride) with statistically significant antiarrhythmic activity in aconitine and CaCl2 arrhythmia models.
Об авторах
G. Mokrov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Автор, ответственный за переписку.
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
A. Likhosherstov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
V. Barchukov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
V. Stolyaruk
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
I. Tsorin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
M. Vititnova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
A. Rebeko
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
S. Kryzhanovskii
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
T. Gudasheva
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
Россия, 8 Baltiiskaya St., Moscow, 125315
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