Specific Antiviral Activity of Pyrimidinedispirotripiperazinium Alone and in Combination with Acyclovir on a Herpes-Simplex-Virus Infection Model
- Авторы: Novoselova E.1, Ryabova O.1, Leneva I.2, Makarov V.1
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Учреждения:
- A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
- I. I. Mechnikov Research Institute of Vaccines and Sera
- Выпуск: Том 53, № 9 (2019)
- Страницы: 781-785
- Раздел: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/246007
- DOI: https://doi.org/10.1007/s11094-019-02079-9
- ID: 246007
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Аннотация
Efficacious antiviral analogs of viral nucleoside DNA-polymerase inhibitors are used to treat infections caused by herpes simplex virus (HSV) although their widespread use in clinical practice has caused drug-resistant HSV strains to develop. The drug substance pyrimidine-dispirotripiperazinium or 3,3-(2-methyl-5-nitropyrimidin-4,6-diyl)-bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride (PDSTP) was previously synthesized by us and possessed high antiherpetic activity in vitro. The antiherpetic efficacy of the new drug substance was evaluated in vivo using a herpetic encephalitis mouse model and various treatment regimes (i.p. and peroral administration, monotherapy, combination therapy with acyclovir).
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Об авторах
E. Novoselova
A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: helen.novoselova@gmail.com
Россия, 33-2b, Leninskii Prosp., Moscow, 119071
O. Ryabova
A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: helen.novoselova@gmail.com
Россия, 33-2b, Leninskii Prosp., Moscow, 119071
I. Leneva
I. I. Mechnikov Research Institute of Vaccines and Sera
Email: helen.novoselova@gmail.com
Россия, 5 Malyi, Kazennyi Pereul., Moscow, 105064
V. Makarov
A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: helen.novoselova@gmail.com
Россия, 33-2b, Leninskii Prosp., Moscow, 119071