Specific Antiviral Activity of Pyrimidinedispirotripiperazinium Alone and in Combination with Acyclovir on a Herpes-Simplex-Virus Infection Model
- Authors: Novoselova E.A.1, Ryabova O.B.1, Leneva I.A.2, Makarov V.A.1
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Affiliations:
- A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
- I. I. Mechnikov Research Institute of Vaccines and Sera
- Issue: Vol 53, No 9 (2019)
- Pages: 781-785
- Section: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/246007
- DOI: https://doi.org/10.1007/s11094-019-02079-9
- ID: 246007
Cite item
Abstract
Efficacious antiviral analogs of viral nucleoside DNA-polymerase inhibitors are used to treat infections caused by herpes simplex virus (HSV) although their widespread use in clinical practice has caused drug-resistant HSV strains to develop. The drug substance pyrimidine-dispirotripiperazinium or 3,3-(2-methyl-5-nitropyrimidin-4,6-diyl)-bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride (PDSTP) was previously synthesized by us and possessed high antiherpetic activity in vitro. The antiherpetic efficacy of the new drug substance was evaluated in vivo using a herpetic encephalitis mouse model and various treatment regimes (i.p. and peroral administration, monotherapy, combination therapy with acyclovir).
About the authors
E. A. Novoselova
A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Author for correspondence.
Email: helen.novoselova@gmail.com
Russian Federation, 33-2b, Leninskii Prosp., Moscow, 119071
O. B. Ryabova
A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: helen.novoselova@gmail.com
Russian Federation, 33-2b, Leninskii Prosp., Moscow, 119071
I. A. Leneva
I. I. Mechnikov Research Institute of Vaccines and Sera
Email: helen.novoselova@gmail.com
Russian Federation, 5 Malyi, Kazennyi Pereul., Moscow, 105064
V. A. Makarov
A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences
Email: helen.novoselova@gmail.com
Russian Federation, 33-2b, Leninskii Prosp., Moscow, 119071