A Novel UV-Spectrophotometric Method for Simultaneous Estimation of Amlodipine and Captopril
- Авторы: Murtaza G.1, Akhtar Y.1, Mahmood T.2, Abid S.1, Makreski P.3
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Учреждения:
- Department of Pharmacy, COMSATS University Islamabad
- Department of Chemistry, COMSATS University Islamabad
- Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University
- Выпуск: Том 52, № 11 (2019)
- Страницы: 952-958
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245552
- DOI: https://doi.org/10.1007/s11094-019-01932-1
- ID: 245552
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Аннотация
An UV-spectrophotometric method for simultaneous determination of amlodipine and captopril has been developed and validated. Simultaneous equation method is applied for the quantification of both drugs, which is based upon the measurement of absorbance at two wavelengths, λmax = 236 and 213 nm for amlodipine and captopril, respectively, in 0.1 N HCl solutions. The calibration curves for amlodipine and captopril are linear in concentration ranges of 0.195 – 100 and 0.39 – 100 μg/mL, respectively. Accuracy of the method is 98 and 99% for amlodipine and captopril, respectively. The inter-day precision for amlodipine and captopril in terms of RSD is 10 and 8%, while the intra-day RSD is 6 and 9%, respectively. Sensitivity of the method in term of the limit of detection for amlodipine and captopril is 0.195 and 0.39 μg, respectively. The method gives 98% reproducible results.
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Об авторах
Ghulam Murtaza
Department of Pharmacy, COMSATS University Islamabad
Email: petremak@pmf.ukim.mk
Пакистан, Lahore Campus, Lahore
Yasmeen Akhtar
Department of Pharmacy, COMSATS University Islamabad
Email: petremak@pmf.ukim.mk
Пакистан, Abbottabad Campus, Abbottabad
Tariq Mahmood
Department of Chemistry, COMSATS University Islamabad
Email: petremak@pmf.ukim.mk
Пакистан, Abbottabad Campus, Abbottabad
Syed Abid
Department of Pharmacy, COMSATS University Islamabad
Email: petremak@pmf.ukim.mk
Пакистан, Abbottabad Campus, Abbottabad
Petre Makreski
Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University
Автор, ответственный за переписку.
Email: petremak@pmf.ukim.mk
Македония, Arhimedova 5, Skopje, 1000