Antiproliferative Evaluation of (E)-3-(3-(Allyloxy)-2-Methoxyphenyl)-1-(2,4,6-Trimethoxyphenyl)Prop-2-En-1-One as a Novel Apoptosis Inducer Against Prostate Cancer PC-3 Cells
- Авторы: Fu D.1, Li P.2, Kuang Y.3, Jiang L.3, Zhu M.1, Li S.2, Zheng G.2, Zhang R.2, Zhang S.2, Li J.2
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Учреждения:
- School of Pharmaceutical Sciences and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University
- School of Basic Medicine, Zhengzhou University
- The Second Affiliated Hospital of Zhengzhou University
- Выпуск: Том 52, № 11 (2019)
- Страницы: 917-922
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245536
- DOI: https://doi.org/10.1007/s11094-019-01926-z
- ID: 245536
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Аннотация
(E)-3-(3-(Allyloxy)-2-methoxyphenyl)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-one displayed potent antiproliferative activity against the PC-3 cell line. For colony assay, it can inhibit the colony formation at a concentration of 10 μM. Morphological changes of PC-3 cells were determined using DAPI (4′,6-diamidino-2-phenylindole) staining and chromatin condensation. Treatment with this compound at 10 μM induced apoptosis from 2.0% to 30.4% compared with control according to flow cytometry analysis. It also induced the downregulation of apoptosis-related markers Bcl-2 and XIAP (X-linked inhibitor of apoptosis protein). However, treatment with NAC (N-acetyl-L-cysteine) almost completely attenuated chalcone-induced cell inhibition and cell apoptosis in PC-3 cells.
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Об авторах
Dong-Jun Fu
School of Pharmaceutical Sciences and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University
Email: fade3532@163.com
Китай, Zhengzhou, 450001
Ping Li
School of Basic Medicine, Zhengzhou University
Email: fade3532@163.com
Китай, Zhengzhou, 450001
Yi-Rui Kuang
The Second Affiliated Hospital of Zhengzhou University
Email: fade3532@163.com
Китай, Zhengzhou, 450014
Li-Le Jiang
The Second Affiliated Hospital of Zhengzhou University
Email: fade3532@163.com
Китай, Zhengzhou, 450014
Ming-Chao Zhu
School of Pharmaceutical Sciences and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University
Email: fade3532@163.com
Китай, Zhengzhou, 450001
Si-Chen Li
School of Basic Medicine, Zhengzhou University
Email: fade3532@163.com
Китай, Zhengzhou, 450001
Guo Zheng
School of Basic Medicine, Zhengzhou University
Email: fade3532@163.com
Китай, Zhengzhou, 450001
Rui Zhang
School of Basic Medicine, Zhengzhou University
Email: fade3532@163.com
Китай, Zhengzhou, 450001
Sai-Yang Zhang
School of Basic Medicine, Zhengzhou University
Автор, ответственный за переписку.
Email: celeron16@163.com
Китай, Zhengzhou, 450001
Jiang-Feng Li
School of Basic Medicine, Zhengzhou University
Автор, ответственный за переписку.
Email: fade3532@163.com
Китай, Zhengzhou, 450001