Efficient Synthesis of 21-Acetoxypregna-1,4,9(11),16-Tetraene-3,20-Dione, a Key Intermediate in the Synthesis of Highly Active Fluorinated Corticosteroids from 9α-Hydroxyandrostenedione
- Авторы: Andryushina V.1, Stytsenko T.1, Karpova N.1, Yaderets V.1, Dzhavakhiya V.1
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Учреждения:
- Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
- Выпуск: Том 52, № 9 (2018)
- Страницы: 776-780
- Раздел: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/245460
- DOI: https://doi.org/10.1007/s11094-018-1898-y
- ID: 245460
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Аннотация
An efficient synthesis of 21-acetoxypregna-1,4,9(11),16-tetraene-3,20-dione, a key intermediate in the synthesis of highly active fluorinated corticosteroids from phytosterols, was developed. The method consisted of an original sequence of chemical and microbiological reactions and could be used to synthesize betamethasone, sinaflan, triamcinolone, and other fluorinated corticoids.
Об авторах
V. Andryushina
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: andryushina@rambler.ru
Россия, Moscow, 117312
T. Stytsenko
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Email: andryushina@rambler.ru
Россия, Moscow, 117312
N. Karpova
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Email: andryushina@rambler.ru
Россия, Moscow, 117312
V. Yaderets
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Email: andryushina@rambler.ru
Россия, Moscow, 117312
V. Dzhavakhiya
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Email: andryushina@rambler.ru
Россия, Moscow, 117312