Efficient Synthesis of 21-Acetoxypregna-1,4,9(11),16-Tetraene-3,20-Dione, a Key Intermediate in the Synthesis of Highly Active Fluorinated Corticosteroids from 9α-Hydroxyandrostenedione
- Авторлар: Andryushina V.1, Stytsenko T.1, Karpova N.1, Yaderets V.1, Dzhavakhiya V.1
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Мекемелер:
- Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
- Шығарылым: Том 52, № 9 (2018)
- Беттер: 776-780
- Бөлім: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/245460
- DOI: https://doi.org/10.1007/s11094-018-1898-y
- ID: 245460
Дәйексөз келтіру
Аннотация
An efficient synthesis of 21-acetoxypregna-1,4,9(11),16-tetraene-3,20-dione, a key intermediate in the synthesis of highly active fluorinated corticosteroids from phytosterols, was developed. The method consisted of an original sequence of chemical and microbiological reactions and could be used to synthesize betamethasone, sinaflan, triamcinolone, and other fluorinated corticoids.
Авторлар туралы
V. Andryushina
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: andryushina@rambler.ru
Ресей, Moscow, 117312
T. Stytsenko
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Email: andryushina@rambler.ru
Ресей, Moscow, 117312
N. Karpova
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Email: andryushina@rambler.ru
Ресей, Moscow, 117312
V. Yaderets
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Email: andryushina@rambler.ru
Ресей, Moscow, 117312
V. Dzhavakhiya
Federal Research Center Fundamentals of Biotechnology, Russian Academy of Sciences
Email: andryushina@rambler.ru
Ресей, Moscow, 117312