Synthesis and Neuropsychotropic Activity of Indole-Containing Gamma-Aminobutyric Acid Derivatives
- Авторы: Berestovitskaya V.1, Vasil’eva O.1, Ostroglyadov E.1, Aleksandrova S.2, Tyurenkov I.3, Merkushenkova O.3, Bagmetova V.3
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Учреждения:
- Herzen State Pedagogical University of Russia
- Pskov State University
- Volgograd State Medical University
- Выпуск: Том 52, № 5 (2018)
- Страницы: 392-396
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245205
- DOI: https://doi.org/10.1007/s11094-018-1827-0
- ID: 245205
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Аннотация
A series of indole-containing γ-aminobutyric acids (GABA) were synthesized via alkaline hydrolysis of 4-(indol-3-yl)-2-pyrrolidones. Their structures were confirmed by IR, PMR, and 13C NMR spectroscopy. Studies of the pharmacological properties of 4-amino-3-indolylbutanoic acids (GABA derivatives) showed that they possessed neuropsychotropic activity, the spectrum of which depended on the acid molecular structure. Nootropic properties prevailed for 4-amino-3-(indol-3-yl)butanoic acid; anxiolytic activity, for 4-amino-3-(1-benzylindol-3-yl)butanoic acid.
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Об авторах
V. Berestovitskaya
Herzen State Pedagogical University of Russia
Автор, ответственный за переписку.
Email: kohrgpu@yandex.ru
Россия, 48 nab. R. Moiki, St. Petersburg, 191186
O. Vasil’eva
Herzen State Pedagogical University of Russia
Email: kohrgpu@yandex.ru
Россия, 48 nab. R. Moiki, St. Petersburg, 191186
E. Ostroglyadov
Herzen State Pedagogical University of Russia
Email: kohrgpu@yandex.ru
Россия, 48 nab. R. Moiki, St. Petersburg, 191186
S. Aleksandrova
Pskov State University
Email: kohrgpu@yandex.ru
Россия, 2 Lenin Sq., Pskov, 180000
I. Tyurenkov
Volgograd State Medical University
Email: kohrgpu@yandex.ru
Россия, 1 Pavshikh Bortsov Sq., Volgograd, 400131
O. Merkushenkova
Volgograd State Medical University
Email: kohrgpu@yandex.ru
Россия, 1 Pavshikh Bortsov Sq., Volgograd, 400131
V. Bagmetova
Volgograd State Medical University
Email: kohrgpu@yandex.ru
Россия, 1 Pavshikh Bortsov Sq., Volgograd, 400131